The In Vitro and In Vivo Study on Self-Nanoemulsifying Drug Delivery System (SNEDDS) Based on Insulin-Phospholipid Complex

被引：59
|
作者：
Zhang, Qianyu [3 ]
He, Na [3 ]
Zhang, Li [3 ]
Zhu, Feng [3 ]
Chen, Qiuxia [3 ]
Qin, Yao [3 ]
Zhang, Zhirong [3 ]
Zhang, Qiang [2 ]
Wang, Shuang [1 ]
He, Qin [3 ]
机构：
[1] Sichuan Univ, W China Hosp, Chengdu 610041, Peoples R China
[2] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
[3] Sichuan Univ, W China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China
来源：
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY | 2012年 / 8卷 / 01期
关键词：
Insulin-Phospholipid Complex (IPC); Self-Nanoemulsifying Drug Delivery Systems (SNEDDS); MDCK Monolayer; Diabetic Models; Enhanced Oral Absorption; INTESTINAL LYMPHATIC TRANSPORT; ORAL DELIVERY; ABSORPTION; NANOPARTICLES; FORMULATION; PERMEABILITY; DESIGN;
D O I：
10.1166/jbn.2012.1371
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
Self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of insulin after oral administration, where insulin was complexed with phospholipid to achieve a better liposolubility in the form of insulin-phospholipid complex (IPC). IPC was formulated into the oil phase of SNEDDS by solvent-evaporation method. The formula of IPC-SNEDDS was optimized and characterized. Data showed that SNEDDS as a drug vehicle did not exhibit an obvious inhibition over MDCK cells, and it can facilitate the transport of IPC across MDCK cell monolayer. IPC-SNEDDS could enhance the absorption of insulin after oral administration and yielded a pronounced hypoglycemic effect on diabetic Wistar rats. All these suggested that IPC-SNEDDS has a great potential for oral delivery of insulin.
引用
收藏
页码：90 / 97
页数：8
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