How to Choose In Vitro Systems to Predict In Vivo Drug Clearance: A System Pharmacology Perspective

被引：5

作者：

Wang, Lei ^{[1
,2
]}

Chiang, ChienWei ^{[3
,4
]}

Liang, Hong ^{[1
,2
]}

Wu, Hengyi ^{[3
,4
]}

Feng, Weixing ^{[1
,5
]}

Quinney, Sara K. ^{[3
,6
]}

Li, Jin ^{[1
,2
]}

Li, Lang ^{[3
,7
]}

机构：

[1] Harbin Engn Univ, Coll Automat, Bioinformat Res Ctr, Harbin 150001, Heilongjiang, Peoples R China

[2] Harbin Engn Univ, Inst Biomed Engn, Coll Automat, Harbin 150001, Heilongjiang, Peoples R China

[3] Indiana Univ, Sch Med, Ctr Computat Biol & Bioinformat, Indianapolis, IN 46202 USA

[4] Indiana Univ, Sch Informat & Comp, Indianapolis, IN 46202 USA

[5] Harbin Engn Univ, Coll Automat, Pattern Recognit & Intelligent Syst Inst, Harbin 150001, Heilongjiang, Peoples R China

[6] Indiana Univ, Sch Med, Dept Obstet & Gynecol, Indianapolis, IN 46202 USA

[7] Indiana Univ, Sch Med, Dept Med & Mol Genom, Indianapolis, IN 46202 USA

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

基金：

中国国家自然科学基金;

关键词：

PHYSIOLOGICALLY-BASED PHARMACOKINETICS; INTRINSIC CLEARANCE; HEPATIC-CLEARANCE; METABOLISM; HEPATOCYTES; HUMANS; MODEL; ADME; PHARMACODYNAMICS; DEXTROMETHORPHAN;

D O I：

10.1155/2015/857327

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The use of in vitro metabolism data to predict human clearance has become more significant in the current prediction of large scale drug clearance for all the drugs. The relevant information (in vitro metabolism data and in vivo human clearance values) of thirty-five drugs that satisfied the entry criteria of probe drugs was collated from the literature. Then the performance of different in vitro systems including Escherichia coli system, yeast system, lymphoblastoid system and baculovirus system is compared after in vitro-in vivo extrapolation. Baculovirus system, which can provide most of the data, has almost equal accuracy as the other systems in predicting clearance. And in most cases, baculovirus system has the smaller CV in scaling factors. Therefore, the baculovirus system can be recognized as the suitable system for the large scale drug clearance prediction.

引用

页数：9

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