Liposomal Codelivery of Doxorubicin and Andrographolide Inhibits Breast Cancer Growth and Metastasis

被引：55

作者：

Kang, Xuejia ^{[1
,2
]}

Zheng, Zenin ^{[1
,2
]}

Liu, Zehua ^{[1
,2
]}

Wang, Huiyuan ^{[2
]}

Zhao, Yuge ^{[2
,3
]}

Zhang, Wenyuan ^{[2
]}

Shi, Mingjie ^{[2
]}

He, Yang ^{[2
]}

Cao, Yang ^{[4
]}

Xu, Qin ^{[1
]}

Peng, Chengyuan ^{[2
]}

Huang, Yongzhuo ^{[2
]}

机构：

[1] Guangzhou Univ Chinese Med, Inst Trop Med, Guangzhou 510405, Guangdong, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China

[3] Nanchang Univ, Coll Pharm, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China

[4] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Guangzhou 510405, Guangdong, Peoples R China

来源：

MOLECULAR PHARMACEUTICS | 2018年 / 15卷 / 04期

关键词：

cell-penetrating peptide; doxorubicin; andrographolide; liposome; angiogenesis; breast cancer; CELL-PENETRATING PEPTIDES; RESISTANT; ANGIOGENESIS;

D O I：

10.1021/acs.molpharmaceut.7b01164

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Effective treatment of metastatic (stage N) breast cancers remains a formidable challenge. To address this issue, a cell-penetrating peptide assisted liposomal system was developed for codelivery of doxorubicin and andrographolide. This nanomedicine-based combination therapy showed the ability to inhibit the in vitro migration and invasion of 4T1 cells through the wound healing and transwell invasion assays. Furthermore, this delivery system exhibited the enhanced accumulation in the tumor tissues and deep intratumoral penetration. The synergistic effect of doxorubicin and andrographolide led to an evident inhibition of tumor growth in an orthotopic breast tumor mouse model and efficient prevention of lung metastasis. The therapeutic mechanism was associated with the anti-angiogenesis effect. In conclusion, this nanomedicine-based combination therapy provides a potential method for overcoming metastatic breast cancers.

引用

页码：1618 / 1626

页数：9

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