TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

被引：56
|
作者：
Chen, Jiayu [1 ,2 ]
Wan, Miao [1 ]
Hua, Jing [3 ]
Sun, Yi [1 ,2 ]
Lv, Zheng [2 ]
Li, Wei [2 ]
Liu, Lei [1 ,3 ]
机构：
[1] Sch Pharmaceut Sci, Jinan 250012, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Sch Pharm, Dept Pharmaceut Anal, Jinan 250355, Shandong, Peoples R China
[3] Guangxi Normal Univ, Minist Educ China, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 47期
基金：
美国国家科学基金会;
关键词：
C-H BONDS; STRUCTURALLY DIVERSE; TERTIARY-AMINES; TOLUENE DERIVATIVES; CATALYZED SYNTHESIS; METHYL ARENES; ACTIVATION; C(SP(3))-H; SP(3); ALKYLATION;
D O I：
10.1039/c5ob01763g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An effective and metal-free oxidative cross-dehydrogenative coupling (CDC) of N-heterocycles with diverse aldehydes has been established in the presence of TBHP/TFA. The scope with respect to aldehyde and N-heterocycle components is broad, allowing facile synthesis of a broad range of structurally diverse C-1-acyl substituted heterocycles in good efficiency.
引用
收藏
页码：11561 / 11566
页数：6
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