TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

被引：56
|
作者：
Chen, Jiayu [1 ,2 ]
Wan, Miao [1 ]
Hua, Jing [3 ]
Sun, Yi [1 ,2 ]
Lv, Zheng [2 ]
Li, Wei [2 ]
Liu, Lei [1 ,3 ]
机构：
[1] Sch Pharmaceut Sci, Jinan 250012, Peoples R China
[2] Shandong Univ Tradit Chinese Med, Sch Pharm, Dept Pharmaceut Anal, Jinan 250355, Shandong, Peoples R China
[3] Guangxi Normal Univ, Minist Educ China, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 47期
基金：
美国国家科学基金会;
关键词：
C-H BONDS; STRUCTURALLY DIVERSE; TERTIARY-AMINES; TOLUENE DERIVATIVES; CATALYZED SYNTHESIS; METHYL ARENES; ACTIVATION; C(SP(3))-H; SP(3); ALKYLATION;
D O I：
10.1039/c5ob01763g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An effective and metal-free oxidative cross-dehydrogenative coupling (CDC) of N-heterocycles with diverse aldehydes has been established in the presence of TBHP/TFA. The scope with respect to aldehyde and N-heterocycle components is broad, allowing facile synthesis of a broad range of structurally diverse C-1-acyl substituted heterocycles in good efficiency.
引用
收藏
页码：11561 / 11566
页数：6
相关论文
共 50 条
  • [31] Fe-Catalyzed Cross-Dehydrogenative Coupling Reactions
    Lv, Leiyang
    Li, Zhiping
    TOPICS IN CURRENT CHEMISTRY, 2016, 374 (04)
  • [32] Copper-Mediated Cross-Dehydrogenative Coupling Reaction of Pyrrole and Indole Derivatives with Thiols
    Ma, Wenbo
    Xu, Yue
    Gu, Qilin
    Zheng, Tao
    Gu, Linghui
    EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2024, 27 (08)
  • [33] Electrochemical Regioselective Cross-Dehydrogenative Coupling of Indoles with Xanthenes
    Chen, Xinyu
    Liu, Hongqiang
    Gao, Hui
    Li, Pinhua
    Miao, Tao
    Li, Hongji
    JOURNAL OF ORGANIC CHEMISTRY, 2022, 87 (02) : 1056 - 1064
  • [34] En Route to Intermolecular Cross-Dehydrogenative Coupling Reactions
    Huang, Chia-Yu
    Kang, Hyotaik
    Li, Jianbin
    Li, Chao-Jun
    JOURNAL OF ORGANIC CHEMISTRY, 2019, 84 (20) : 12705 - 12721
  • [35] Oxidative cross-esterification of dithiolanes with alcohols through a cross-dehydrogenative coupling (CDC)/deprotection sequence
    Fu, Liang
    Yao, Chang-Jiang
    Chang, Ning-Jie
    Chen, Jia-Rong
    Lu, Liang-Qiu
    Xiao, Wen-Jing
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2012, 10 (03) : 506 - 508
  • [36] Indium-catalyzed oxidative cross-dehydrogenative coupling of chromenes with 1,3-dicarbonyls and aryl rings
    Li, Fanmei
    Meng, Zhilin
    Hua, Jing
    Li, Wei
    Lou, Hongxiang
    Liu, Lei
    ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 13 (20) : 5710 - 5715
  • [37] Heterogeneous Photocatalysis as a Potent Tool for Organic Synthesis: Cross-Dehydrogenative C-C Coupling of N-Heterocycles with Ethers Employing TiO2/N-Hydroxyphthalimide System under Visible Light
    Lopat'eva, Elena R.
    Krylov, Igor B.
    Segida, Oleg O.
    Merkulova, Valentina M.
    Ilovaisky, Alexey I.
    Terent'ev, Alexander O.
    MOLECULES, 2023, 28 (03):
  • [38] Cross-dehydrogenative coupling reaction using copper oxide impregnated on magnetite in deep eutectic solvents
    Marset, Xavier
    Perez, Juana M.
    Ramon, Diego J.
    GREEN CHEMISTRY, 2016, 18 (03) : 826 - 833
  • [39] Asymmetric Catalytic Carbon-Carbon Coupling Reactions via Cross-Dehydrogenative Coupling Reactions
    Zhang, Yan
    Feng, Bainian
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2014, 34 (12) : 2406 - 2411
  • [40] O2-Mediated Te(II)-Redox Catalysis for the Cross-Dehydrogenative Coupling of Indoles
    Cremer, Christopher
    Patureau, Frederic W.
    JACS AU, 2022, 2 (06): : 1318 - 1323
12345