TBHP/TFA mediated oxidative cross-dehydrogenative coupling of N-heterocycles with aldehydes

被引：58

作者：

Chen, Jiayu ^{[1
,2
]}

Wan, Miao ^{[1
]}

Hua, Jing ^{[3
]}

Sun, Yi ^{[1
,2
]}

Lv, Zheng ^{[2
]}

Li, Wei ^{[2
]}

Liu, Lei ^{[1
,3
]}

机构：

[1] Sch Pharmaceut Sci, Jinan 250012, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Sch Pharm, Dept Pharmaceut Anal, Jinan 250355, Shandong, Peoples R China

[3] Guangxi Normal Univ, Minist Educ China, Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2015年 / 13卷 / 47期

基金：

美国国家科学基金会;

关键词：

C-H BONDS; STRUCTURALLY DIVERSE; TERTIARY-AMINES; TOLUENE DERIVATIVES; CATALYZED SYNTHESIS; METHYL ARENES; ACTIVATION; C(SP(3))-H; SP(3); ALKYLATION;

D O I：

10.1039/c5ob01763g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An effective and metal-free oxidative cross-dehydrogenative coupling (CDC) of N-heterocycles with diverse aldehydes has been established in the presence of TBHP/TFA. The scope with respect to aldehyde and N-heterocycle components is broad, allowing facile synthesis of a broad range of structurally diverse C-1-acyl substituted heterocycles in good efficiency.

引用

收藏

页码：11561 / 11566

页数：6

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