Connecting cancer to the asymmetric division of stem cells

被引：40

作者：

Wodarz, A

Gonzalez, C

机构：

[1] Univ Gottingen, DFG Res Ctr Mol Physiol Brain, Dept Stem Cell Biol, D-37077 Gottingen, Germany

[2] PCB, ICREA, Inst Recerca Biomed, Cell Div Grp, Barcelona 08028, Spain

来源：

CELL | 2006年 / 124卷 / 06期

关键词：

D O I：

10.1016/j.cell.2006.03.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two studies, one in this issue of Cell (Betschinger et al., 2006) and the other in Developmental Cell (Lee et al., 2006a) show that the cell-fate determinant Brain Tumor (Brat) suppresses self-renewal in one of the daughter cells that arise from the asymmetric division of a neural stem cell. This work suggests a mechanism by which loss of polarity in stem cells may lead to tumorigenesis.

引用

页码：1121 / 1123

页数：3

共 11 条

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