Anti-Inflammatory Activity of Schizonepeta tenuifolia through the Inhibition of MAPK Phosphorylation in Mouse Peritoneal Macrophages

被引：20

作者：

Kim, Su-Jin ^{[1
,2
]}

Kim, Jung-Sun ^{[1
]}

Choi, In-Young ^{[1
]}

Kim, Dong-Hyun ^{[1
]}

Kim, Min-Cheol ^{[1
]}

An, Hyo-Jin ^{[2
]}

Na, Ho-Jeong ^{[2
]}

Kim, Na-Hyung ^{[2
]}

Moon, Phil-Dong ^{[4
]}

Myung, Noh-Yil ^{[3
]}

Lee, Ju-Young ^{[6
]}

Jeong, Hyun-Ja ^{[5
]}

Um, Jae-Young ^{[2
,3
]}

Shin, Tae-Yong ^{[7
]}

Kim, Hyung-Min ^{[2
]}

Hong, Seung-Heon ^{[1
]}

机构：

[1] Wonkwang Univ, Coll Pharm, Iksan 570749, Jeonbuk, South Korea

[2] Kyung Hee Univ, Coll Oriental Med, Inst Oriental Med, Seoul 130701, South Korea

[3] Kyung Hee Univ, Acupuncture & Meridian Sci Res Ctr, Seoul 130701, South Korea

[4] Kyung Hee Univ, Coll Oriental Med, Oriental Med Sci Ctr, Seoul 130701, South Korea

[5] Hoseo Univ, Biochip Res Ctr, Asan 336795, Chungnam, South Korea

[6] ShinSung Coll, Dept Herb Sci, Chungnam 343861, South Korea

[7] Woosuk Univ, Coll Pharm, Jeonju, South Korea

来源：

AMERICAN JOURNAL OF CHINESE MEDICINE | 2008年 / 36卷 / 06期

关键词：

Schizonepeta tenuifolia; Tumor Necrosis Factor-alpha; Interleukin-6; Cyclooxygenase-2; Inducible Nitric Oxide Synthase; MAPK;

D O I：

10.1142/S0192415X0800648X

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Schizonepeta tenuifolia (ST) is a well-known herb to treat the cold and its associated headache. However, the anti-inflammatory mechanism of ST in mouse peritoneal macrophages is not clear. In this study, we demonstrated that ST inhibited lipopolysaccaride (LPS)- induced tumor necrosis factor (TNF)-alpha and interleukin (IL)-6 production. The maximal inhibition rate of TNF-alpha and IL-6 production by ST (2 mg/ml) was 48.01 +/- 2.8% and 56.45 +/- 2.8%, respectively. During the inflammatory process, cyclooxygenase (COX)- 2 and inducible nitric oxide synthase (iNOS) were increased in mouse peritoneal macrophages. However, treated with ST decreased the protein level of COX-2 and iNOS, as well as the production of PGE(2) and NO in LPS-stimulated mouse peritoneal macrophages. In addition, ST inhibited the phosphorylation of MAPK. Taken together, the results of this study suggest an important molecular mechanism by which ST reduces inflammation, which may explain its beneficial effect in the regulation of inflammatory reactions.

引用

页码：1145 / 1158

页数：14

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