Determination of amitriptyline using electrogenerated chemiluminescence

被引：18

作者：

Dolman, SJL ^{[1
]}

Greenway, GM ^{[1
]}

机构：

[1] UNIV HULL,SCH CHEM,KINGSTON HULL HU6 7RX,N HUMBERSIDE,ENGLAND

来源：

ANALYTICAL COMMUNICATIONS | 1996年 / 33卷 / 04期

关键词：

D O I：

10.1039/ac9963300139

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A novel method for the selective and sensitive determination of amitriptyline, a tricyclic antidepressant, using electrogenerated chemiluminescence (ECL) is described. The ECL mechanism is based on the reaction between tris(2,2'-bipyridyl)ruthenium(II) [Ru(bpy)(3)(2+)] and the tertiary amino group on amitriptyline. After optimizing the experimental conditions, a calibration over three orders of magnitude of concentration, was obtained. A linear calibration plot was constructed in order to evaluate the limit of detection, which was determined as 3.0 x 10(-7) mol l(-1) (94 ppb) with an average % S-r of 2.14 for 5 replicate measurements.

引用

页码：139 / 141

页数：3