T helper type 1 cells in asthma: friend or foe?

被引：29

作者：

Stephens, Robin ^{[1
]}

Eisenbarth, Stephanie C. ^{[2
]}

Chaplin, David D. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Microbiol, 845 19th St South,BBRB 276-11, Birmingham, AL 35294 USA

[2] Yale Univ, Dept Immunol, Sch Med, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY | 2002年 / 2卷 / 01期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1097/00130832-200202000-00006

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

A large body of research supports a pathogenic role for T helper 2 cells in asthma, although T helper 1 cell-type responses may also contribute. Using the principle of T helper cell cross-regulation, investigators have attempted to regulate the pathological effects of T helper 2 cells using regimens that may promote T helper 1 cell-type inflammation. In this review, we propose that the use of factors that promote T helper 1 cell differentiation and activation to treat asthma may be counterproductive, and that alternate regulatory approaches should be explored. (C) 2002 Lippincott Williams & Wilkins.

引用

页码：31 / 37

页数：7

共 60 条

[1] Functional diversity of helper T lymphocytes [J].

Abbas, AK ;

Murphy, KM ;

Sher, A .

NATURE, 1996, 383 (6603) :787-793

[2] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].

Akbari, O ;

DeKruyff, RH ;

Umetsu, DT .

NATURE IMMUNOLOGY, 2001, 2 (08) :725-731

[3] Stability and commitment in T helper cell development [J].

Asnagli, H ;

Murphy, KM .

CURRENT OPINION IN IMMUNOLOGY, 2001, 13 (02) :242-247

[4] Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: Differences from hydrocortisone-treated dendritic cells [J].

Bellinghausen, I ;

Brand, U ;

Steinbrink, K ;

Enk, AH ;

Knop, J ;

Saloga, J .

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (02) :242-249

[5] Fasciola hepatica suppresses a protective Th1 response against Bordetella pertussis [J].

Brady, MT ;

O'Neill, SM ;

Dalton, JP ;

Mills, KHG .

INFECTION AND IMMUNITY, 1999, 67 (10) :5372-5378

[6] Effects of recombinant human interleukin-12 on eosinophils, airway hyper-responsiveness, and the late asthmatic response [J].

Bryan, SA ;

O'Connor, BJ ;

Matti, S ;

Leckie, MJ ;

Kanabar, V ;

Khan, J ;

Warrington, SJ ;

Renzetti, L ;

Rames, A ;

Bock, JA ;

Boyce, MJ ;

Hansel, TT ;

Holgate, ST ;

Barnes, PJ .

LANCET, 2000, 356 (9248) :2149-2153

[7] ELEVATED RELEASE OF TUMOR-NECROSIS-FACTOR-ALPHA AND INTERFERON-GAMMA BY BRONCHOALVEOLAR LEUKOCYTES FROM PATIENTS WITH BRONCHIAL-ASTHMA [J].

CEMBRZYNSKANOWAK, M ;

SZKLARZ, E ;

INGLOT, AD ;

TEODORCZYKINJEYAN, JA .

AMERICAN REVIEW OF RESPIRATORY DISEASE, 1993, 147 (02) :291-295

[8] T helper 1 cells and interferon γ regulate allergic airway inflammation and mucus production [J].

Cohn, L ;

Homer, RJ ;

Niu, NQ ;

Bottomly, K .

JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 190 (09) :1309-1317

[9] IL-4 promotes airway eosinophilia by suppressing IFN-γ production:: Defining a novel role for IFN-γ in the regulation of allergic airway inflammation [J].

Cohn, L ;

Herrick, C ;

Niu, NQ ;

Homer, RJ ;

Bottomly, K .

JOURNAL OF IMMUNOLOGY, 2001, 166 (04) :2760-2767

[10]

Cohn L, 1999, J IMMUNOL, V162, P6178

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