Greener synthesis of ZnO and Ag-ZnO nanoparticles using Silybum marianum for diverse biomedical applications

被引：138

作者：

Hameed, Safia ^{[1
]}

Khalil, Ali T. ^{[2
,3
,4
]}

Ali, Muhammad ^{[1
]}

Numan, Muhammad ^{[1
]}

Khamlich, Saleh ^{[3
,4
]}

Shinwari, Zabta K. ^{[2
,5
]}

Maaza, Malik ^{[2
,4
]}

机构：

[1] Quaid I Azam Univ, Dept Biotechnol, Islamabad, Pakistan

[2] Qarshi Univ, Dept Eastern Med & Surg, Lahore, Pakistan

[3] Univ South Africa, UNESCO UNISA Africa Chair Nanosci & Nanotechnol, Coll Grad Studies, Pretoria, South Africa

[4] IThemba LABS, Nanosci African Network NANOAFNET, Mat Res Dept, Cape Town, South Africa

[5] Pakistan Acad Sci, Islamabad, Pakistan

来源：

NANOMEDICINE | 2019年 / 14卷 / 06期

基金：

新加坡国家研究基金会;

关键词：

Ag-ZnO; antileishmanial; antimicrobial; antioxidant; enzyme inhibition; nanocomposite; nanoparticles; nanoscosmaceutical; Silybum marianum; ZnO; ZINC-OXIDE NANOPARTICLES; LEAF EXTRACT; IN-VITRO; ANTIBACTERIAL ACTIVITY; PHYTOCHEMICAL ANALYSIS; METHANOLIC EXTRACT; CANCER-CELLS; BIOSYNTHESIS; ANTIOXIDANT; NANOSTRUCTURES;

D O I：

10.2217/nnm-2018-0279

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: To investigate the physical and biological properties of Silybum marianum inspired ZnO nanoparticles (NPs), Ag-ZnO heterostructures. Experiment: Nanoparticles were characterized using ultraviolet-visible and infrared spectroscopy, x-ray diffraction, high resolution electron microscopy, zeta potential and thermo-gravimetric analysis etc. Results: Ag-ZnO-NPs indicated slightly higher antimicrobial potential then ZnO-NPs. Good antileishmanial (IC50 = 246 mu g/ml for Ag-ZnO; 341 mu g/ml for ZnO) and antioxidant potential while moderate enzyme inhibition is reported. 2, 2-Diphenyl 1-picrylhydrazyl radical scavenging of Ag-ZnO was higher relative to ZnO-NPs. Nanocosmaceutical formulation of nanoparticles indicated stable antimicrobial performance. Conclusion: Biosynthesized nanoparticles indicated interesting biological properties and should be subjected to further research to establish their pharmacological relevance.

引用

页码：655 / 673

页数：19

共 77 条

[1] Milk thistle (Silybum marianum): A concise overview on its chemistry, pharmacological, and nutraceutical uses in liver diseases [J].

Abenavoli, Ludovico ;

Izzo, Angelo A. ;

Milic, Natasa ;

Cicala, Carla ;

Santini, Antonello ;

Capasso, Raffaele .

PHYTOTHERAPY RESEARCH, 2018, 32 (11) :2202-2213

[2] Zinc oxide nanoparticles selectively induce apoptosis in human cancer cells through reactive oxygen species [J].

Akhtar, Mohd Javed ;

Ahamed, Maqusood ;

Kumar, Sudhir ;

Khan, M. A. Majeed ;

Ahmad, Javed ;

Alrokayan, Salman A. .

INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 :845-857

[3] Biogenic synthesis of Zinc oxide nanostructures from Nigella sativa seed: Prospective role as food packaging material inhibiting broad-spectrum quorum sensing and biofilm [J].

Al-Shabib, Nasser A. ;

Husain, Fohad Mabood ;

Ahmed, Faheem ;

Khan, Rais Ahmad ;

Ahmad, Iqbal ;

Alsharaeh, Edreese ;

Khan, Mohd Shahnawaz ;

Hussain, Afzal ;

Rehman, Md Tabish ;

Yusuf, Mohammad ;

Hassan, Iftekhar ;

Khan, Javed Masood ;

Ashraf, Ghulam Md ;

Alsalme, Ali Mohammed ;

Al-Ajmi, Mohamed F. ;

Tarasov, Vadim V. ;

Aliev, Gjumrakch .

SCIENTIFIC REPORTS, 2016, 6

[4] Effect of Phenolic Compounds on the Synthesis of Gold Nanoparticles and Its Catalytic Activity in the Reduction of Nitro Compounds [J].

Alegria, Elisabete C. B. A. ;

Ribeiro, Ana P. C. ;

Mendes, Marta ;

Ferraria, Ana M. ;

Botelho do Rego, Ana M. ;

Pombeiro, Armando J. L. .

NANOMATERIALS, 2018, 8 (05)

[5] ZnO nanostructure fabrication in different solvents transforms physio-chemical, biological and photodegradable properties [J].

Ali, Attarad ;

Ambreen, Sidra ;

Javed, Rabia ;

Tabassum, Saira ;

ul Haq, Ihsan ;

Zia, Muhammad .

MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2017, 74 :137-145

[6] Inhibitory Effects of Flavonolignans from Silybum marianum (L.) Gaertn (Milk Thistle) on Function of Aldehyde Oxidase and Xanthine Oxidase in Rats [J].

Alizadeh, Nafiseh ;

Eskandani, Morteza ;

Tondro, Khalil ;

Rashidi, Mohamad-Reza ;

Nazemiyeh, Hossein .

LETTERS IN DRUG DESIGN & DISCOVERY, 2018, 15 (03) :256-262

[7] Superior performance of V2O5 as hole selective contact over other transition metal oxides in silicon heterojunction solar cells [J].

Almora, Osbel ;

Gerling, Luis G. ;

Voz, Cristobal ;

Alcubilla, Ramon ;

Puigdollers, Joaquim ;

Garcia-Belmonte, Germa .

SOLAR ENERGY MATERIALS AND SOLAR CELLS, 2017, 168 :221-226

[8] Preparation and Characterization of Zeolite\Zinc Oxide-Copper Oxide Nanocomposite: Antibacterial Activities [J].

Alswat, Abdullah A. ;

Bin Ahmad, Mansor ;

Saleh, Tawfik A. .

COLLOID AND INTERFACE SCIENCE COMMUNICATIONS, 2017, 16 :19-24

[9] Chronic exposure of zinc oxide nanoparticles causes deviant phenotype in Drosophila melanogaster [J].

Anand, Avnika Singh ;

Prasad, Dipti N. ;

Singh, Shashi Bala ;

Kohli, Ekta .

JOURNAL OF HAZARDOUS MATERIALS, 2017, 327 :180-186

[10] Toxicity on Dengue Mosquito Vectors Through Myristica fragrans-Synthesized Zinc Oxide Nanorods, and Their Cytotoxic Effects on Liver Cancer Cells (HepG2) [J].

Ashokan, Anila P. ;

Paulpandi, Manickam ;

Dinesh, Devakumar ;

Murugan, Kadarkarai ;

Vadivalagan, Chithravel ;

Benelli, Giovanni .

JOURNAL OF CLUSTER SCIENCE, 2017, 28 (01) :205-226

← 1 2 3 4 5 6 7 8 →