Novel Caffeic Acid Phenethyl Ester (CAPE) Analogues as Immunoregulatory Agents: Synthesis and SAR Study

被引：0
|
作者：
Liu, Tianliang [1 ]
Deng, Li [1 ,2 ]
Li, Xiaoli [1 ]
Du, Qin [1 ]
Chen, Li [1 ]
Liu, Xiaohua [1 ]
Li, Zhubo [1 ]
机构：
[1] Southwest Univ, Coll Pharmaceut Sci, Chongqing 400716, Peoples R China
[2] Chongqing Ctr Adverse Drug React Monitoring, Chongqing 400014, Peoples R China
来源：
LATIN AMERICAN JOURNAL OF PHARMACY | 2013年 / 32卷 / 03期
关键词：
Caffeic acid phenethyl ester analogues; Immunoregulatory activity; Structure and activity relationship (SAR); KAPPA-B; CELLS; ANTIOXIDANT; INHIBITOR; PROPOLIS; STRESS; GROWTH; DAMAGE; DNA;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Two novel caffeic acid phenethyl ester (CAPE) analogues, (E)-4-hydroxyphenethyl 3-(3,4-dihydroxyphenyl)acrylate (HPDHPA) and (E)-4-nitrophenethyl 3-(3,4-dihydroxyphenyl) acrylate (NPDH-PA) were synthesized according to the relationship between the antitumor activity and ClogP values of the known CAPE derivatives calculated by CambridgeSoft Corporation Chemoffice 8.0. The effects of the two synthesized CAPE analogues on increasing the white blood cell (WBC) count, spleen index, thymus index and the level of nitric oxide against the immunosuppressed mice were studied. The results indicated that the immunoregulatory activity increased at the low dose of HPDHPA and NPDHPA (HPDHPA group > NPDHPA group > CAPE group) (3 mg/kg), and the activity increased with the decrease of ClogP. In addition, the immunoregulatory activity was affected by other chemical parameters like total energy at high dose of the novel CAPE analogues.
引用
收藏
页码：329 / 334
页数：6
相关论文
共 50 条
  • [31] Caffeic Acid Phenethyl Ester (CAPE) Attenuates Paclitaxel-induced Peripheral Neuropathy: A Mechanistic Study
    Kulkarni, Namrata Pramod
    Vaidya, Bhupesh
    Narula, Acharan S.
    Sharma, Shyam Sunder
    CURRENT NEUROVASCULAR RESEARCH, 2022, 19 (03) : 293 - 302
  • [32] Caffeic acid phenethyl ester (CAPE): cornerstone pharmacological studies and drug delivery systems
    Yordanov, Yordan
    PHARMACIA, 2019, 66 (04) : 223 - 231
  • [33] Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis
    Tayman, Cuneyt
    Tonbul, Alparslan
    Kosus, Aydin
    Hirfanoglu, Ibrahim Murat
    Haltas, Hacer
    Uysal, Sema
    Tatli, Mustafa Mansur
    Andiran, Fatih
    PEDIATRIC SURGERY INTERNATIONAL, 2011, 27 (11) : 1179 - 1189
  • [34] In Vivo and In Vitro Antneoplastic Actions of Caffeic Acid Phenethyl Ester (CAPE): Therapeutic Perspectives
    Akyol, Sumeyya
    Ozturk, Gulfer
    Ginis, Zeynep
    Armutcu, Ferah
    Yigitoglu, M. Ramazan
    Akyol, Omer
    NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2013, 65 (04): : 515 - 526
  • [35] CAFFEIC ACID PHENETHYL ESTER (CAPE) - NATURAL SOURCES, ANALYTICAL PROCEDURES AND SYNTHETIC APPROACHES
    Bankova, Vassya
    Trusheva, Boryana
    Popova, Milena
    COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES, 2018, 71 (09): : 1157 - 1169
  • [36] Caffeic acid phenethyl ester (CAPE) ameliorates cisplatin-induced hepatotoxicity in rabbit
    Kart, Asim
    Cigremis, Yilmaz
    Karaman, Musa
    Ozen, Hasan
    EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY, 2010, 62 (01) : 45 - 52
  • [37] The Effect of Caffeic Acid Phenethyl Ester (CAPE) Against Cholestatic Liver Injury in Rats
    Coban, Sacid
    Yildiz, Fahrettin
    Terzi, Alpaslan
    Al, Behcet
    Ozgor, Dincer
    Ara, Cengiz
    Polat, Alaattin
    Esrefoglu, Mukaddes
    JOURNAL OF SURGICAL RESEARCH, 2010, 159 (02) : 674 - 679
  • [38] Vascular effects of caffeic acid phenethyl ester (CAPE) on isolated rat thoracic aorta
    Cicala, C
    Morello, S
    Iorio, C
    Capasso, R
    Borrelli, F
    Mascolo, N
    LIFE SCIENCES, 2003, 73 (01) : 73 - 80
  • [39] Role of vagal activity on bradicardic and hypotensive effects of caffeic acid phenethyl ester (CAPE)
    Mustafa Iraz
    Ersin Fadillioglu
    Seda Tasdemir
    Selim Erdogan
    Cardiovascular Toxicology, 2005, 5 : 391 - 396
  • [40] Protective effects of caffeic acid phenethyl ester (CAPE) on intestinal damage in necrotizing enterocolitis
    Cuneyt Tayman
    Alparslan Tonbul
    Aydın Kosus
    Ibrahim Murat Hirfanoglu
    Hacer Haltas
    Sema Uysal
    Mustafa Mansur Tatli
    Fatih Andiran
    Pediatric Surgery International, 2011, 27 : 1179 - 1189
12345