The effectiveness of berberine on noise-induced hearing loss: a rat model

被引:3
作者
Kilic, Korhan [1 ]
Sakat, Muhammed Sedat [1 ]
Sahin, Abdulkadir [1 ]
Yildirim, Serkan [2 ]
Dortbudak, Muhammet Bahaeddin [2 ]
机构
[1] Ataturk Univ, Fac Med, Dept Otorhinolaryngol, Erzurum, Turkey
[2] Ataturk Univ, Fac Vet, Dept Pathol, Erzurum, Turkey
来源
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA | 2022年 / 68卷 / 09期
关键词
Acoustic trauma; Berberine; Noise-induced hearing loss; COCHLEAR; PROTECTS; TRAUMA; BRAIN;
D O I
10.1590/1806-9282.20220758
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE: Noise-induced hearing loss is a preventable form of hearing loss that has serious social and economic impacts. This study aimed to investigate the protective effect of berberine, a potent antioxidant and anti-inflammatory agent, against Noise-induced hearing loss.METHODS:After applying distortion product otoacoustic emission, 28 female Sprague-Dawley rats were randomly divided into four groups. Group 1 was designated as acoustic trauma group, and rats in this group were exposed to white noise for 12 h at an intensity of 4 kHz 110 dB sound pressure level. Group 2 was the control group. Group 3 was designated as the berberine group, and 100 mg/kg of berberine was administered to rats in this group by intragastric lavage for five consecutive days. Group 4 was designated as the acoustic trauma+berberine group. distortion product otoacoustic emission was repeated on the 6th day of the study and cochlear tissues of rats were dissected for histopathological and immunohistochemical analyses after sacrificing rats.RESULTS: The distortion product otoacoustic emission results showed a significant decrease in signal-noise ratio values at higher frequencies in rats of the trauma group compared to those in other groups. Acoustic trauma caused severe histopathological impairment at cochlear structures together with severe 8-hydroxy-2-deoxyguanosine expression. Rats in the acoustic trauma+berberine group showed mild histopathological changes with mild 8-hydroxy-2-deoxyguanosine expression and better signal-noise ratio values. CONCLUSION: The histopathological and audiological findings of this experimental study showed that berberine provides protection in Noise -induced hearing loss and may have the potential for use in acoustic trauma-related hearing losses.
引用
收藏
页码:1330 / 1336
页数:7
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