Selective copper catalysed aromatic N-arylation in water

被引：65

作者：

Engel-Andreasen, Jens ^{[1
]}

Shimpukade, Bharat ^{[1
]}

Ulven, Trond ^{[1
]}

机构：

[1] Univ So Denmark, Dept Phys Chem & Pharm, DK-5230 Odense M, Denmark

来源：

GREEN CHEMISTRY | 2013年 / 15卷 / 02期

关键词：

ARYL HALIDES; COUPLING REACTIONS; CROSS-COUPLINGS; MILD CONDITIONS; C-N; IMIDAZOLES; LIGANDS; LOADINGS; NITROGEN; SYSTEM;

D O I：

10.1039/c2gc36589h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

4,7-Dipyrrolidinyl-1,10-phenanthroline (DPPhen) was identified as an efficient ligand for copper catalysed selective aromatic N-arylation in water. N-Arylation of indoles, imidazoles and purines proceeds with moderate to excellent yields and complete selectivity over aliphatic amines. Aqueous medium and the possibility for low metal and ligand loadings give the process a benign environmental profile.

引用

页码：336 / 340

页数：5

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