Skull Base Chordomas Clinical Features, Prognostic Factors, and Therapeutics

被引：19

作者：

Jahangiri, Arman ^{[1
]}

Jian, Brian ^{[1
]}

Miller, Liane ^{[1
]}

El-Sayed, Ivan H. ^{[1
,2
]}

Aghi, Manish K. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol Surg, Ctr Minimally Invas Skull Base Surg, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Otolaryngol Head & Neck Surg, San Francisco, CA 94115 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2013年 / 24卷 / 01期

关键词：

Chordoma; Skull base; Clivus; Radiation therapy; Radiosurgery; GROWTH-FACTOR RECEPTOR; PROTON RADIATION-THERAPY; UPPER CERVICAL-SPINE; CRANIAL BASE; CLIVAL CHORDOMA; STEREOTACTIC RADIOSURGERY; FOLLOW-UP; IMMUNOHISTOCHEMICAL ANALYSIS; SACROCOCCYGEAL CHORDOMA; INTRACRANIAL CHORDOMAS;

D O I：

10.1016/j.nec.2012.08.007

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Chordomas of the skull base are one of the rarest intracranial malignancies that arise from ectopic remnants of embryonal notochod. The proximity of many chordomas to neurovascular structures makes gross total resection difficult, and the tendency for recurrence leads to the routine use of adjuvant postoperative radiation. Several surgical approaches are used ranging from extensive craniotomies to minimally invasive endonasal endoscopic approaches. In this review, the histopathology and epidemiology, imaging characteristics, surgical approaches, adjuvant therapies, prognostic factors, and molecular biology of chordomas are described.

引用

页码：79 / +

页数：11

共 110 条

[81] Multimodality management of 26 skull-base chordomas with 4-year mean follow-up:: experience at a single institution [J].