GABAergic anxiolytic drug in water increases migration behaviour in salmon

被引：61

作者：

Hellstrom, Gustav ^{[1
]}

Klaminder, Jonatan ^{[1
]}

Finn, Fia ^{[1
]}

Persson, Lo ^{[2
]}

Alanara, Anders ^{[2
]}

Jonsson, Micael ^{[1
]}

Fick, Jerker ^{[3
]}

Brodin, Tomas ^{[1
]}

机构：

[1] Umea Univ, Dept Ecol & Environm Sci, SE-90187 Umea, Sweden

[2] Swedish Univ Agr Sci, Dept Wildlife Fish & Environm Studies, SE-90183 Umea, Sweden

[3] Umea Univ, Dept Chem, SE-90187 Umea, Sweden

来源：

NATURE COMMUNICATIONS | 2016年 / 7卷

基金：

瑞典研究理事会;

关键词：

ATLANTIC SALMON; DOWNSTREAM MIGRATION; SMOLTING PERIOD; FISH BEHAVIOR; SALAR L; ECOLOGY; ANXIETY; CONSERVATION; CONTAMINANTS; ZEBRAFISH;

D O I：

10.1038/ncomms13460

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Migration is an important life-history event in a wide range of taxa, yet many migrations are influenced by anthropogenic change. Although migration dynamics are extensively studied, the potential effects of environmental contaminants on migratory physiology are poorly understood. In this study we show that an anxiolytic drug in water can promote downward migratory behaviour of Atlantic salmon (Salmo salar) in both laboratory setting and in a natural river tributary. Exposing salmon smolt to a dilute concentration of a GABAA receptor agonist (oxazepam) increased migration intensity compared with untreated smolt. These results implicate that salmon migration may be affected by human-induced changes in water chemical properties, such as acidification and pharmaceutical residues in wastewater effluent, via alterations in the GABAA receptor function.

引用

页数：7

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