Pd-Catalyzed Oxidative Annulation of Hydrazides with Isocyanides: Synthesis of 2-Amino-1,3,4-oxadiazoles

被引：96

作者：

Fang, Tao ^{[1
]}

Tan, Qitao ^{[1
]}

Ding, Zhengwei ^{[1
]}

Liu, Bingxin ^{[1
]}

Xu, Bin ^{[1
,2
,3
]}

机构：

[1] Shanghai Univ, Dept Chem, Innovat Drug Res Ctr, Shanghai 200444, Peoples R China

[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China

[3] E China Normal Univ, Dept Chem, Shanghai Key Lab Green Chem & Chem Proc, Shanghai 200062, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 09期

基金：

中国国家自然科学基金;

关键词：

BENZOIC-ACID HYDRAZIDES; N BOND FORMATION; X-RAY-STRUCTURE; VINBLASTINE ANALOGS; EFFICIENT ACCESS; MULTICOMPONENT REACTIONS; REGIOSELECTIVE SYNTHESIS; 3-COMPONENT REACTION; DIRECT AMINATION; INSERTION;

D O I：

10.1021/ol5006449

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium-catalyzed oxidative annulation reaction was developed through sequential isocyanide insertions into N-H and O-H bonds of hydrazides, which provides an efficient access to valuable 2-amino-1,3,4-oxadiazoles and their derivatives.

引用

页码：2342 / 2345

页数：4

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