Effect of IL-18 on IL-1β and sIL-1RII production by human neutrophils

被引：0
|
作者：
Jablonska, E [1 ]
Izycka, A [1 ]
Wawrusiewicz, N [1 ]
机构：
[1] Med Acad Bialystok, Dept Immunol, PL-15230 Bialystok, Poland
来源：
ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS | 2002年 / 50卷 / 02期
关键词：
neutrophil; interleukin; 18; 1; beta; soluble interleukin 1 receptor II;
D O I：
暂无
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
In the present study we investigated the effect of interleukin 18 (IL-18) on the production of IL-1beta and soluble IL-1 receptor II (sIL-IRII) by human neutrophils. The results obtained indicate that recombinant human IL-18 (rhIL-18) induces IL-1beta and, to a lesser extent, sIL-IRII production by human neutrophil isolated from peripheral blood. However, this effect was less important than lipopolysaccharide (LPS) stimulation. Additionally, our observations suggest that IL-18 can induce priming of neutrophils for IL-1beta and, to a lesser extent, sIL-IRII production by LPS-stimulated cells. The ability of IL-18 to serve as an effective modulator for IL-1beta and its regulatory protein may have significance in the inflammatory and immune reactions mediated by IL-1beta.
引用
收藏
页码：139 / 141
页数：3
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