Glucose metabolism alterations and follow-up study of a non-diabetic adult population

被引：0

作者：

Vernet Vernet, M. ^{[1
]}

Sender Palacios, M. J. ^{[1
]}

Jovell Fernandez, E. ^{[1
]}

Casals Riera, R. ^{[1
]}

Tor Figueras, E. ^{[1
]}

Anglada Barcelo, J. ^{[2
]}

机构：

[1] Consorci Sanit Terrassa, Ctr Atenc Primaria Terrassa Nord, Barcelona, Spain

[2] Hosp Mutua Terrassa, Serv Endocrinol, Barcelona, Spain

来源：

REVISTA CLINICA ESPANOLA | 2009年 / 209卷 / 01期

关键词：

Insulin resistance; Pancreatic function of beta cells; Type 2 diabetes mellitus; Impaired fasting glucose; IMPAIRED FASTING GLUCOSE; TYPE-2; DIABETES-MELLITUS; RISK SPANISH POPULATION; INSULIN-RESISTANCE; TOLERANCE TEST; PREVALENCE; DIAGNOSIS; HEALTH; SPAIN; HOORN;

D O I：

10.1016/S0014-2565(09)70351-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To determine the appearance of type 2 diabetes mellitus (DM2) and impaired fasting glucose (IFG) at five years of follow-up in a known non-diabetic population. Patients and methods. Design: nested case control studies (case s-control into a cohort) developed in two stages: 1) identification and characterization of the cohort and 2) follow-up. Study population: representative sample of a non-diabetic population between 40 and 75 years old attended in a Primary Health Center. Results. Identification: 326 persons, 2.1% of whom were diagnosed of previously unknown DM2 and 7.3% of IFG. Insulin resistance (IR) was higher in patients with IFG and pancreatic function of beta cells (PFBC) was higher in the population without glucose metabolism alteration. Follow-up: 121 persons, 9.7% of whom evolved to DM2 (all with IFG). IFG proportion at the end of the follow-up was 23.96%. Conclusions. At 5 years of follow-up, more than 1/3 of the population studied developed DM2 or IFG. These diagnoses were related with IR and PFBC. (C) 2008 Elsevier Espana, S.L. All rights reserved.

引用

页码：3 / 8

页数：6

共 25 条

[1]

Balkau B, 2002, DIABETES METAB, V28, P364

[2] Prevalence of diabetes in Catalonia (Spain): an oral glucose tolerance test-based population study [J].

Castell, C ;

Tresserras, R ;

Serra, J ;

Goday, A ;

Lloveras, G ;

Salleras, L .

DIABETES RESEARCH AND CLINICAL PRACTICE, 1999, 43 (01) :33-40

[3]

Costa B, 2001, Aten Primaria, V28, P193

[4] Impact of the American Diabetes Association diagnosis criteria on high-risk Spanish population [J].

Costa, B ;

Franch, J ;

Martín, F ;

Morató, J ;

Donado, A ;

Basora, J ;

Daniel, J .

DIABETES RESEARCH AND CLINICAL PRACTICE, 1999, 46 (01) :75-81

[5] Undiagnosed diabetes and impaired glucose metabolism on high-risk Spanish population.: The IGT Study [J].

Costa, B ;

Martín, F ;

Donado, A ;

Parera, F ;

Piñol, JL ;

Basora, J ;

Daniel, J .

MEDICINA CLINICA, 2000, 114 (16) :601-608

[6] Prevalence of diabetes and impaired fasting glucose in adults in the US population - National Health and Nutrition Examination Survey 1999-2002 [J].

Cowie, Catherine C. ;

Engelgau, Michael M. ;

Rust, Keith F. ;

Saydah, Sharon H. ;

Byrd-Holt, Danita D. ;

Williams, Desmond E. ;

Eberhardt, Mark S. ;

Geiss, Linda S. ;

Flegal, Katherine M. ;

Gregg, Edward W. .

DIABETES CARE, 2006, 29 (06) :1263-1268

[7] Relation of impaired fasting and postload glucose with incident type 2 diabetes in a Dutch population - The Hoorn study [J].

de Vegt, F ;

Dekker, JM ;

Jager, A ;

Hienkens, E ;

Kostense, PJ ;

Stehouwer, CDA ;

Nijpels, G ;

Bouter, LM ;

Heine, RJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (16) :2109-2113

[8]

DEPABLOSVELASCO PL, 2007, MED CLIN-BARCELONA, V8, P3

[9]

Genuth S, 2003, DIABETES CARE, V26, P3160

[10] INSULIN-RESISTANCE - SYNDROME OR TENDENCY [J].

GODSLAND, IF ;

STEVENSON, JC .

LANCET, 1995, 346 (8967) :100-103

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