The Relative Body Weight Gain From Early to Middle Life Adulthood Associated With Later Life Risk of Diabetes: A Nationwide Cohort Study

被引：2

作者：

Xu, Min ^{[1
,2
]}

Qi, Yan ^{[1
,2
]}

Chen, Gang ^{[3
]}

Qin, Yingfen ^{[4
]}

Wu, Shengli ^{[5
]}

Wang, Tiange ^{[1
,2
]}

Zhao, Zhiyun ^{[1
,2
]}

Xu, Yu ^{[1
,2
]}

Li, Mian ^{[1
,2
]}

Chen, Li ^{[6
]}

Chen, Lulu ^{[7
]}

Chen, Yuhong ^{[1
,2
]}

Deng, Huacong ^{[8
]}

Gao, Zhengnan ^{[9
]}

Huo, Yanan ^{[10
]}

Li, Qiang ^{[11
]}

Liu, Chao ^{[12
]}

Luo, Zuojie ^{[4
]}

Mu, Yiming ^{[13
]}

Qin, Guijun ^{[14
]}

Shen, Feixia ^{[15
]}

Shi, Lixin ^{[16
]}

Su, Qing ^{[17
]}

Wan, Qin ^{[18
]}

Wang, Guixia ^{[19
]}

Wang, Shuangyuan ^{[1
,2
]}

Wang, Youmin ^{[20
]}

Hu, Ruying ^{[21
]}

Xu, Yiping ^{[22
]}

Yan, Li ^{[23
]}

Yang, Tao ^{[24
]}

Yu, Xuefeng ^{[25
]}

Zhang, Yinfei ^{[26
]}

Zeng, Tianshu ^{[7
]}

Tang, Xulei ^{[27
]}

Ye, Zhen ^{[21
]}

Zhao, Jiajun ^{[28
]}

Bi, Yufang ^{[1
,2
]}

Ning, Guang ^{[1
,2
]}

Lu, Jieli ^{[1
,2
]}

Wang, Weiqing ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Endocrine & Metab Dis, Dept Endocrine & Metab Dis,Sch Med, Shanghai, Peoples R China

[2] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Natl Clin Res Ctr Metab Dis,Sch Med, Shanghai Key Lab Endocrine Tumor,Key Lab Endocrin, Shanghai, Peoples R China

[3] Fujian Med Univ, Fujian Prov Hosp, Dept Endocrinol, Fuzhou, Peoples R China

[4] Guangxi Med Univ, Affiliated Hosp 1, Dept Endocrinol, Nanning, Peoples R China

[5] Karamay Municipal Peoples Hosp, Dept Endocrinol, Karamay, Xinjiang, Peoples R China

[6] Shandong Univ, Qilu Hosp, Dept Endocrinol, Jinan, Peoples R China

[7] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China

[8] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Chongqing, Peoples R China

[9] Dalian Municipal Cent Hosp, Dept Endocrinol, Dalian, Peoples R China

[10] Nanchang Univ, Jiangxi Prov People S Hosp, Dept Endocrinol, Nanchang, Jiangxi, Peoples R China

[11] Harbin Med Univ, Affiliated Hosp 2, Dept Endocrinol, Harbin, Peoples R China

[12] Jiangsu Prov Hosp Integrat Chinese & Western Med, Dept Endocrinol, Nanjing, Peoples R China

[13] Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China

[14] Zhengzhou Univ, Affiliated Hosp 1, Dept Endocrinol, Zhengzhou, Peoples R China

[15] Wenzhou Med Univ, Affiliated Hosp 1, Dept Endocrinol, Wenzhou, Peoples R China

[16] Guiyang Med Coll, Affiliated Hosp, Dept Endocrinol, Guiyang, Peoples R China

[17] Shanghai Jiao Tong Univ, Xinhua Hosp, Sch Med, Dept Endocrinol, Shanghai, Peoples R China

[18] Southwest Med Univ, Affiliated Hosp, Dept Endocrinol, Luzhou, Peoples R China

[19] First Hosp Jilin Univ, Dept Endocrinol, Changchun, Peoples R China

[20] Anhui Med Univ, Affiliated Hosp 1, Dept Endocrinol, Hefei, Peoples R China

[21] Zhejiang Prov Ctr Dis Control & Prevent, Inst Chron Dis, Hangzhou, Peoples R China

[22] Shanghai Jiao Tong Univ, Ruijin Hosp, Clin Trials Ctr, Sch Med, Shanghai, Peoples R China

[23] Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Endocrinol, Guangzhou, Peoples R China

[24] Nanjing Med Univ, Affiliated Hosp 1, Dept Endocrinol, Nanjing, Peoples R China

[25] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Endocrinol, Wuhan, Peoples R China

[26] Cent Hosp Shanghai Jiading Dist, Dept Endocrinol, Shanghai, Peoples R China

[27] Lanzhou Univ, Hosp 1, Dept Endocrinol, Lanzhou, Peoples R China

[28] Shandong Prov Hosp, Dept Endocrinol, Jinan, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

Body weight gain; early life adulthood; prospective cohort; type; 2; diabetes; later life risk; obesity; MASS INDEX; AGE; POPULATION; PREVALENCE; VALIDITY; OBESITY; HEALTH; CHINA;

D O I：

10.3389/fendo.2022.927067

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

AimTo determine the effect of decade-based body weight gain from 20 to 50 years of age on later life diabetes risk. Methods35,611 non-diabetic participants aged >= 50 years from a well-defined nationwide cohort were followed up for average of 3.6 years, with cardiovascular diseases and cancers at baseline were excluded. Body weight at 20, 30, 40, and 50 years was reported. The overall 30 years and each 10-year weight gain were calculated from the early and middle life. Cox regression models were used to estimate risks of incident diabetes. ResultsAfter 127,745.26 person-years of follow-up, 2,789 incident diabetes were identified (incidence rate, 2.18%) in 25,289 women (mean weight gain 20-50 years, 7.60 kg) and 10,322 men (7.93 kg). Each 10-kg weight gain over the 30 years was significantly associated with a 39.7% increased risk of incident diabetes (95% confidence interval [CI], 1.33-1.47); weight gain from 20-30 years showed a more prominent effect on the risk of developing diabetes before 60 years than that of after 60 years (Hazard ratio, HR = 1.084, 95% CI [1.049-1.121], P <0.0001 vs. 1.015 [0.975-1.056], P = 0.4643; P (Interaction)=0.0293). It showed a stable effect of the three 10-year intervals weight gain on risk of diabetes after 60 years (HR=1.055, 1.038, 1.043, respectively, all P < 0.0036). ConclusionsThe early life weight gain showed a more prominent effect on developing diabetes before 60 years than after 60 years; however, each-decade weight gain from 20 to 50 years showed a similar effect on risk developing diabetes after 60 years.

引用

页数：12

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