Peroxisome proliferator-activated receptor-δ attenuates colon carcinogenesis

被引：187

作者：

Harman, FS

Nicol, CJ

Marin, HE

Ward, JM

Gonzalez, FJ

Peters, JM ^{[1
]}

机构：

[1] Penn State Univ, Dept Vet Sci, University Pk, PA 16802 USA

[2] Penn State Univ, Ctr Mol Toxicol & Carcinogenesis, University Pk, PA 16802 USA

[3] Penn State Univ, Grad Program Biochem Microbiol & Mol Biol, University Pk, PA 16802 USA

[4] NCI, Lab Metab, Bethesda, MD 20892 USA

[5] NCI, Vet & Tumor Pathol Sect, Off Lab Anim Resources, Frederick, MD 21702 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 05期

关键词：

D O I：

10.1038/nm1026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Peroxisome proliferator-activated receptor-delta (PPAR-delta; also known as PPAR-beta) is expressed at high levels in colon tumors, but its contribution to colon cancer is unclear. We examined the role of PPAR-delta in colon carcinogenesis using PPAR-delta-deficient (Ppard(-/-)) mice. In both the Min mutant and chemically induced mouse models, colon polyp formation was significantly greater in mice nullizygous for PPAR-delta. In contrast to previous reports suggesting that activation of PPAR-delta potentiates colon polyp formation, here we show that PPAR-delta attenuates colon carcinogenesis.

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页码：481 / 483

页数：3

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