Hemorheological alterations in patients with chronic renal failure.: Effect of hemodialysis

被引:0
作者
Martínez, M
Vayá, A
Alvariño, J
Barberá, JL
Ramos, D
López, A
Aznar, J
机构
[1] Dept Biopatol Clin, Unidad Hemooeol, Valencia, Spain
[2] Hosp La Fe, Serv Nefrol, E-46009 Valencia, Spain
[3] Ctr Hemodialisis Gamapal, Valencia, Spain
关键词
hemorheology; renal failure; hemodialysis;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The rheological profile of 45 patients who had kidney failure and were undergoing periodical hemodialysis was studied to ascertain whether they showed rheological alterations and if these alterations improved after hemodialysis. Our results indicate that the patients studied suffer rheological alterations with respect to the control group, specifically increased plasma fibrinogen (436 +/- 119 vs 271 +/- 43 mg/dl, p < 0.001), increased plasma viscosity (1.30 +/- 0.10 vs 1.22 +/- 0.05 mPa.s, p < 0.001), higher erythrocyte aggregability (8.3 +/- 1.2 vs 7.4 +/- 1.4, p < 0.01) and a lower hematocrit (31.2 +/- 5.9 vs 43.4 +/- 3.7, p < 0.001), In contrast, erythrocyte deformability did not seem to be altered with respect to the control group. The analyses carried out immediately after hemodialysis showed that in general the rheological profile worsened during this treatment; then was a significant increase in fibrinogen and in plasma viscosity. The rheological alterations detected may play a role in the development of the atherosclerosis processes often experienced by these patients.
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页码:1 / 6
页数:6
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