Molecular Pathogenesis of Mantle Cell Lymphoma

被引：56

作者：

Navarro, Alba ^{[1
,2
]}

Bea, Silvia ^{[1
,2
,3
]}

Jares, Pedro ^{[1
,2
,3
]}

Campo, Elias ^{[1
,2
,3
]}

机构：

[1] Inst Invest Biomed August Pi & Sunyer, Rossello 149-153, Barcelona 08036, Spain

[2] Ctr Invest Biomed Red Canc, Madrid, Spain

[3] Univ Barcelona, Hosp Clin Barcelona, Hematopathol Unit, Villarroel 170, Barcelona 08036, Spain

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2020年 / 34卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Mantle cell lymphoma; CCND1; SOX11; Molecular pathogenesis; Gene mutations; Genome instability; Cancer hallmarks; GENE-EXPRESSION; CYCLIN D1; PREDICTS SURVIVAL; SOX11; EXPRESSION; PROGNOSTIC VALUE; B-CELLS; INHIBITION; MUTATIONS; DELETIONS; REARRANGEMENT;

D O I：

10.1016/j.hoc.2020.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mantle cell lymphoma (MCL) is a mature B-cell neoplasm with heterogeneous clinical behavior molecularly characterized by the constitutive overexpression of cyclin D1 and deregulation of different signaling pathways. SOX11 expression determines an aggressive phenotype associated with accumulation of many chromosomal alterations and somatic gene mutations. A subset of patients with the SOX11-negative leukemic non-nodal MCL subtype follows an initial indolent clinical evolution and may not require treatment at diagnosis, although eventually may progress to an aggressive disease. We discuss the genetic and molecular alterations with impact on the cancer hallmarks that characterize the lymphomagenesis of the 2 MCL subtypes. © 2020 Elsevier Inc.

引用

页码：795 / 807

页数：13

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