Carotid artery intima-media thickness and stiffness index β changes in normal children: role of age, height and sex

被引:16
作者
Calabro, Maria Pia [1 ]
Carerj, Scipione [2 ]
Russo, Mario Salvatore [2 ]
De Luca, Francesco Letterio [1 ]
Onofrio, Maria Teresa Naso [3 ]
Antonini-Canterin, Francesco [4 ]
Zito, Concetta [2 ]
Oreto, Lilia [2 ]
Manuri, Lucia [1 ]
Khandheria, Bijoy K. [5 ]
Oreto, Giuseppe [2 ]
机构
[1] Univ Messina, Dept Pediat Gynecol Microbiol & Biomed Sci, Messina, Italy
[2] Univ Messina, Dept Clin & Expt Med, Messina, Italy
[3] Univ Messina, Dept SEFISAT, Messina, Italy
[4] Dept Cardiovasc & Atherosclerot Pathol, Pordenone, Italy
[5] Univ Wisconsin, Sch Med & Publ Hlth, Aurora Cardiovasc Serv, Aurora Sinai Aurora St Lukes Med Ctr, Milwaukee, WI 53201 USA
关键词
arterial stiffness; atherosclerosis; paediatric age; CARDIOVASCULAR RISK-FACTORS; PULSE-WAVE VELOCITY; YOUNG-ADULTS; FAMILIAL HYPERCHOLESTEROLEMIA; ENDOTHELIAL DYSFUNCTION; INDEPENDENT PREDICTOR; HYPERTENSIVE PATIENTS; VASCULAR FUNCTION; AORTIC STIFFNESS; FEMORAL ARTERIES;
D O I
10.2459/JCM.0000000000000295
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
AimsThe need for early markers of atherosclerosis in paediatric ages has been emphasized recently. Few data are available on the behaviour of carotid intima-media thickness (cIMT) and arterial stiffness in normal children.MethodsWe studied prospectively 131 healthy children (78 boys), aged 3-16 years, by high-definition ultrasonography and echo-tracking technique in order to evaluate cIMT and stiffness index .ResultsStiffness index underwent a significant age-related increase (P<0.001), and a positive relationship between cIMT and height was found in boys. In addition, stiffness index and cIMT were not related to each other (P=0.97).ConclusionThis study provides information about two markers of subclinical atherosclerosis, cIMT and carotid stiffness index , in normal children aged 3-16 years. We found a significant age-related and height-related increase of stiffness index in both sexes, whereas cIMT was positively related to height only in boys.
引用
收藏
页码:19 / 27
页数:9
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