Facile fabrication of ibuprofen-LDH nanohybrids via a delamination/reassembling process

被引：37

作者：

Lu, Xiaomei ^{[1
]}

Meng, Liming ^{[1
]}

Li, Haiping ^{[1
]}

Du, Na ^{[1
]}

Zhang, Renjie ^{[1
]}

Hou, Wanguo ^{[1
]}

机构：

[1] Shandong Univ, Educ Minist, Key Lab Colloid & Interface Chem, Jinan 250100, Peoples R China

来源：

MATERIALS RESEARCH BULLETIN | 2013年 / 48卷 / 04期

基金：

中国国家自然科学基金; 高等学校博士学科点专项科研基金;

关键词：

Layered compounds; Nanostructures; Intercalation reactions; X-ray diffraction; LAYERED DOUBLE HYDROXIDES; POSITIVELY CHARGED NANOSHEETS; DELAMINATION; RELEASE; INTERCALATION; DRUG; RESTACKING; ANION; XRD;

D O I：

10.1016/j.materresbull.2012.12.057

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

In this paper, a delamination/reassembling method for the facile fabrication of ibuprofen (IBU), a nonsteroidal anti-inflammatory drug, intercalated layered double hydroxide (LDH) nanohybrid was presented. In this method, LDH particles were first delaminated to well dispersed 2D nanosheets in formamide, and then the LDH nanosheets and IBU molecules coassembled into the IBU-LDH nanohybrid. The characteristics of the so-synthesized nanohybrid were the same as that of the IBU-LDH nanohybrids synthesized by the conventional methods including ion exchange, co-precipitation, reconstruction and hydrothermal methods. However, the delamination/reassembling method displayed various remarkable advantages, such as simple procedure, short reaction time, mild condition and high drug loading, compared with the conventional methods. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1512 / 1517

页数：6

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