Sphingosine-1-phosphate receptors and innate immunity

被引：120

作者：

Bryan, Arielle M. ^{[1
]}

Del Poeta, Maurizio ^{[1
,2
,3
]}

机构：

[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

[2] Vet Adm Med Ctr, Northport, NY 11768 USA

[3] SUNY Stony Brook, Div Infect Dis, Stony Brook, NY 11794 USA

来源：

CELLULAR MICROBIOLOGY | 2018年 / 20卷 / 05期

关键词：

G protein coupled receptors; Inhibitors; Innate immunity; Sphingolipid; Sphingosine-1-phosphate; S1P receptors; SPHINGOSINE 1-PHOSPHATE RECEPTOR; PROTEIN-COUPLED RECEPTORS; KILLER-CELL TRAFFICKING; MULTIPLE-SCLEROSIS; LYMPHOCYTE EGRESS; DENDRITIC CELLS; MOLECULAR-CLONING; RHO GTPASES; T-CELLS; FTY720;

D O I：

10.1111/cmi.12836

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sphingosine-1-phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. One well-studied role of S1P signalling is to modulate T-cell trafficking, which has a major impact on adaptive immunity. Compounds that target S1P signalling pathways are of interest for immune system modulation. Recent studies suggest that S1P signalling regulates many more cell types and processes than previously appreciated. This review will summarise current understanding of S1P signalling, focusing on recent novel findings in the roles of S1P receptors in innate immunity.

引用

页数：10

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