Sphingosine-1-phosphate receptors and innate immunity

被引：120

作者：

Bryan, Arielle M. ^{[1
]}

Del Poeta, Maurizio ^{[1
,2
,3
]}

机构：

[1] SUNY Stony Brook, Dept Mol Genet & Microbiol, Stony Brook, NY 11794 USA

[2] Vet Adm Med Ctr, Northport, NY 11768 USA

[3] SUNY Stony Brook, Div Infect Dis, Stony Brook, NY 11794 USA

来源：

CELLULAR MICROBIOLOGY | 2018年 / 20卷 / 05期

关键词：

G protein coupled receptors; Inhibitors; Innate immunity; Sphingolipid; Sphingosine-1-phosphate; S1P receptors; SPHINGOSINE 1-PHOSPHATE RECEPTOR; PROTEIN-COUPLED RECEPTORS; KILLER-CELL TRAFFICKING; MULTIPLE-SCLEROSIS; LYMPHOCYTE EGRESS; DENDRITIC CELLS; MOLECULAR-CLONING; RHO GTPASES; T-CELLS; FTY720;

D O I：

10.1111/cmi.12836

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Sphingosine-1-phosphate (S1P) is a signalling lipid that regulates many cellular processes in mammals. One well-studied role of S1P signalling is to modulate T-cell trafficking, which has a major impact on adaptive immunity. Compounds that target S1P signalling pathways are of interest for immune system modulation. Recent studies suggest that S1P signalling regulates many more cell types and processes than previously appreciated. This review will summarise current understanding of S1P signalling, focusing on recent novel findings in the roles of S1P receptors in innate immunity.

引用

页数：10

共 91 条

[1] Cryptococcal Meningoencephalitis in a Patient With Multiple Sclerosis Treated With Fingolimod [J].

Achtnichts, Lutz ;

Obreja, Otilia ;

Conen, Anna ;

Fux, Christoph A. ;

Nedeltchev, Krassen .

JAMA NEUROLOGY, 2015, 72 (10) :1203-+

[2] DESIGN, SYNTHESIS, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF 2-SUBSTITUTED-2-AMINO-1,3-PROPANEDIOLS - DISCOVERY OF A NOVEL IMMUNOSUPPRESSANT, FTY720 [J].

ADACHI, K ;

KOHARA, T ;

NAKAO, N ;

ARITA, M ;

CHIBA, K ;

MISHINA, T ;

SASAKI, S ;

FUJITA, T .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1995, 5 (08) :853-856

[3] Sphingosine-1-phosphate receptor 2 [J].

Adada, Mohamad ;

Canals, Daniel ;

Hannun, Yusuf A. ;

Obeid, Lina M. .

FEBS JOURNAL, 2013, 280 (24) :6354-6366

[4] Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth facetor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion [J].

Adada, Mohamad M. ;

Canals, Daniel ;

Jeong, Nara ;

Kelkar, Ashwin D. ;

Hernandez-Corbacho, Maria ;

Pulkoski-Gross, Michael J. ;

Donaldson, Jane C. ;

Hannun, Yusuf A. ;

Obeid, Lina M. .

FASEB JOURNAL, 2015, 29 (11) :4654-4669

[5] Novel immunomodulator FTY720 is phosphorylated in rats and humans to form a single stereoisomer.: Identification, chemical proof, and biological characterization of the biologically active species and its enantiomer [J].

Albert, R ;

Hinterding, K ;

Brinkmann, V ;

Guerini, D ;

Müller-Hartwieg, C ;

Knecht, H ;

Simeon, C ;

Streiff, M ;

Wagner, T ;

Welzenbach, K ;

Zécri, F ;

Zollinger, M ;

Cooke, N ;

Francotte, E .

JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (16) :5373-5377

[6] Sphingosine-1-phosphate Lyase Deficiency Produces a Pro-inflammatory Response While Impairing Neutrophil Trafficking [J].

Allende, Maria L. ;

Bektas, Meryem ;

Lee, Bridgin G. ;

Bonifacino, Eliana ;

Kang, Jiman ;

Tuymetova, Galina ;

Chen, WeiPing ;

Saba, Julie D. ;

Proia, Richard L. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (09) :7348-7358

[7] Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720 [J].

Allende, ML ;

Sasaki, T ;

Kawai, H ;

Olivera, A ;

Mi, YD ;

van Echten-Deckert, G ;

Hajdu, R ;

Rosenbach, M ;

Keohane, CA ;

Mandala, S ;

Spiegel, S ;

Proia, RL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (50) :52487-52492

[8]

Althoff E., 2016, Novartis BAF312 reduces the risk of disability progression in pivotal phase III study in secondary progressive MS patients | Novartis

[9] Sphingosine-1-phosphate signaling: unraveling its role as a drug target against infectious diseases [J].

Arish, Mohd ;

Husein, Atahar ;

Kashif, Mohammad ;

Saleem, Mohammed ;

Akhter, Yusuf ;

Rub, Abdur .

DRUG DISCOVERY TODAY, 2016, 21 (01) :133-142

[10] Sphingosine 1-Phosphate Receptor 3-Deficient Dendritic Cells Modulate Splenic Responses to Ischemia-Reperfusion Injury [J].

Bajwa, Amandeep ;

Huang, Liping ;

Kurmaeva, Elvira ;

Gigliotti, Joseph C. ;

Ye, Hong ;

Miller, Jacqueline ;

Rosin, Diane L. ;

Lobo, Peter I. ;

Okusa, Mark D. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2016, 27 (04) :1076-1090

← 1 2 3 4 5 6 7 8 9 10 →