18F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma

被引：19
作者：
Suzuki, Hidenori [1 ]
Kato, Katsuhiko [2 ]
Fujimoto, Yasushi [3 ]
Itoh, Yoshiyuki [4 ]
Hiramatsu, Mariko [3 ]
Maruo, Takashi [3 ]
Naganawa, Shinji [4 ]
Hasegawa, Yasuhisa [1 ]
Nakashima, Tsutomu [3 ]
机构：
[1] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Chikusa Ku, Nagoya, Aichi 4648681, Japan
[2] Nagoya Univ, Sch Hlth Sci, Dept Radiol Technol Hlth Sci, Nagoya, Aichi 4648601, Japan
[3] Nagoya Univ, Dept Otorhinolaryngol, Grad Sch Med, Nagoya, Aichi 4648601, Japan
[4] Nagoya Univ, Dept Radiol, Grad Sch Med, Nagoya, Aichi 4648601, Japan
来源：
ANNALS OF NUCLEAR MEDICINE | 2013年 / 27卷 / 03期
关键词：
F-18-FDG-PET/CT; Hypopharyngeal; Squamous; Cell; Carcinoma; SUVmax; POSITRON-EMISSION-TOMOGRAPHY; PET; GLUT-1; HEAD;
D O I：
10.1007/s12149-013-0686-8
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
We investigated the relationship between overall survival of patients and pretreatment [F-18]-2-fluorodeoxyglucose (F-18-FDG) uptake, assessed by positron emission tomography combined with computed tomography (PET/CT) in hypopharyngeal squamous cell carcinoma. Thirty-one patients who were newly diagnosed as resectable hypopharyngeal squamous cell carcinoma underwent pretreatment F-18-FDG-PET/CT. We used the maximum standardized uptake value (SUVmax) as F-18-FDG uptake. Overall survival rate was calculated by the Kaplan-Meier method. The median SUVmax was 11.53 (range 2.49-22.33). Patients with SUVmax a parts per thousand yen 13 significantly exhibited shorter overall survival in univariate analysis (p < 0.01). Moreover, by Cox proportional hazards model of multivariate analysis, SUVmax a parts per thousand yen 13 was a significant prognostic factor independent of clinical T and N classification, and treatment group (p < 0.02). These results suggested that SUVmax obtained by pretreatment F-18-FDG PET/CT assessment is an important prognostic factor in patients with hypopharyngeal squamous cell carcinoma.
引用
收藏
页码：297 / 302
页数：6
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