18F-FDG-PET/CT predicts survival in hypopharyngeal squamous cell carcinoma

被引：19

作者：

Suzuki, Hidenori ^{[1
]}

Kato, Katsuhiko ^{[2
]}

Fujimoto, Yasushi ^{[3
]}

Itoh, Yoshiyuki ^{[4
]}

Hiramatsu, Mariko ^{[3
]}

Maruo, Takashi ^{[3
]}

Naganawa, Shinji ^{[4
]}

Hasegawa, Yasuhisa ^{[1
]}

Nakashima, Tsutomu ^{[3
]}

机构：

[1] Aichi Canc Ctr Hosp, Dept Head & Neck Surg, Chikusa Ku, Nagoya, Aichi 4648681, Japan

[2] Nagoya Univ, Sch Hlth Sci, Dept Radiol Technol Hlth Sci, Nagoya, Aichi 4648601, Japan

[3] Nagoya Univ, Dept Otorhinolaryngol, Grad Sch Med, Nagoya, Aichi 4648601, Japan

[4] Nagoya Univ, Dept Radiol, Grad Sch Med, Nagoya, Aichi 4648601, Japan

来源：

ANNALS OF NUCLEAR MEDICINE | 2013年 / 27卷 / 03期

关键词：

F-18-FDG-PET/CT; Hypopharyngeal; Squamous; Cell; Carcinoma; SUVmax; POSITRON-EMISSION-TOMOGRAPHY; PET; GLUT-1; HEAD;

D O I：

10.1007/s12149-013-0686-8

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

We investigated the relationship between overall survival of patients and pretreatment [F-18]-2-fluorodeoxyglucose (F-18-FDG) uptake, assessed by positron emission tomography combined with computed tomography (PET/CT) in hypopharyngeal squamous cell carcinoma. Thirty-one patients who were newly diagnosed as resectable hypopharyngeal squamous cell carcinoma underwent pretreatment F-18-FDG-PET/CT. We used the maximum standardized uptake value (SUVmax) as F-18-FDG uptake. Overall survival rate was calculated by the Kaplan-Meier method. The median SUVmax was 11.53 (range 2.49-22.33). Patients with SUVmax a parts per thousand yen 13 significantly exhibited shorter overall survival in univariate analysis (p < 0.01). Moreover, by Cox proportional hazards model of multivariate analysis, SUVmax a parts per thousand yen 13 was a significant prognostic factor independent of clinical T and N classification, and treatment group (p < 0.02). These results suggested that SUVmax obtained by pretreatment F-18-FDG PET/CT assessment is an important prognostic factor in patients with hypopharyngeal squamous cell carcinoma.

引用

页码：297 / 302

页数：6

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