Double 1,3-Dipolar Cycloadditions of Two Nonstabilized Azomethine Ylides for Polycyclic Pyrrolidines

被引：21
作者：
Zhang, Xiaofeng [1 ,2 ]
Qiu, Weiqi [1 ,2 ]
Evans, Jason [1 ,2 ]
Kaur, Manpreet [3 ]
Jasinski, Jerry P. [3 ]
Zhang, Wei [1 ,2 ]
机构：
[1] Univ Massachusetts, Ctr Green Chem, 100 Morrissey Blvd, Boston, MA 02125 USA
[2] Univ Massachusetts, Dept Chem, 100 Morrissey Blvd, Boston, MA 02125 USA
[3] Keene State Coll, Dept Chem, 229 Main St, Keene, NH 03435 USA
来源：
ORGANIC LETTERS | 2019年 / 21卷 / 07期
关键词：
X=Y-ZH SYSTEMS; ONE-POT; INTRAMOLECULAR CYCLOADDITION; STEREOSELECTIVE-SYNTHESIS; DECARBOXYLATIVE ROUTE; POTENTIAL 1,3-DIPOLES; 2-AZAALLYL ANIONS; GENERATION; CONSTRUCTION; AZIRIDINES;
D O I：
10.1021/acs.orglett.9b00487
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Nonstabilized azomethine ylides derived from decarboxylation of oxazolidin-5-ones were used for double 1,3-dipolar cycloadditions in diastereoselective synthesis of pyrrolidine-containing tetracyclic compounds. This is the first example of one-pot and five-component reactions involving two nonstabilized azomethine ylides. Only CO2 and water were generated as byproducts.
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收藏
页码：2176 / 2179
页数：4
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