A Comparison of Aerosol Performance Using Standardized Entrainment Tubes vs. Dry Powder Inhaler Devices

被引：0

作者：

Xu, Zhen ^{[1
]}

Hickey, Anthony J. ^{[2
]}

机构：

[1] Univ N Carolina, Eshelman Sch Pharm, Div Mol Pharmaceut, Chapel Hill, NC 27759 USA

[2] Res Triangle Inst, Res Triangle Pk, NC 27709 USA

来源：

KONA POWDER AND PARTICLE JOURNAL | 2013年 / 30期

关键词：

standardized entrainment tubes; dry powder inhalers; powder aerosol deaggregation equation; inhalation; aerosolization performance; shear stress; fine particle fraction; DISODIUM-CROMOGLYCATE; PARTICLE DETACHMENT; DRUG BLENDS; AIR-FLOW; SURFACES; RESUSPENSION; MONOHYDRATE; VOLUNTEERS; RESISTANCE; DISPERSION;

D O I：

暂无

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

This paper reviews scientific understandings relevant to the dry powder inhaler (DPI) development including turbulent airflow characteristics in the inhaler, microparticle entrainment and deaggregation within the airflow and device. Using standardized entrainment tubes (SETs) and powder aerosol deaggregation equation (PADE), the aerosol performance profile in a shear stress range defined by SETs can be predicted. However, such predictions are based on the hypothesis that the shear stresses characterized from SETs are readily translatable to those of the DPIs'. Two selected model DPIs (Rotahaler and Aerolizer) with either gelatin or HPMC capsules were used to evaluate the FPF at the DPI shear stresses. The performance result using DPIs was close to the predicted FPF using SETs and PADE method. The application of SETs and PADE method can be used for performance prediction of these DPIs.

引用

页码：201 / 210

页数：10

共 32 条

[1]

[Anonymous], 2000, TURBULENT FLOW, DOI DOI 10.1017/CBO9780511840531

[2] Aerodynamic dispersion of cohesive powders: A review of understanding and technology [J].

Calvert, G. ;

Ghadiri, M. ;

Tweedie, R. .

ADVANCED POWDER TECHNOLOGY, 2009, 20 (01) :4-16

[3] Effect of particle size, air flow and inhaler device on the aerosolisation of disodium cromoglycate powders [J].

Chew, NYK ;

Bagster, DF ;

Chan, HK .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2000, 206 (1-2) :75-83

[4] THE RELATIONSHIP BETWEEN POWDER INHALER RESISTANCE AND PEAK INSPIRATORY CONDITIONS IN HEALTHY-VOLUNTEERS - IMPLICATIONS FOR IN-VITRO TESTING [J].

CLARK, AR ;

HOLLINGWORTH, AM .

JOURNAL OF AEROSOL MEDICINE-DEPOSITION CLEARANCE AND EFFECTS IN THE LUNG, 1993, 6 (02) :99-110

[5] MEDICAL AEROSOL INHALERS - PAST, PRESENT, AND FUTURE [J].

CLARK, AR .

AEROSOL SCIENCE AND TECHNOLOGY, 1995, 22 (04) :374-391

[6]

Coates M. S., 2009, PARTICULATE SYSTEMS, P193

[7] Influence of mouthpiece geometry on the aerosol delivery performance of a dry powder inhaler [J].

Coates, Matthew S. ;

Chan, Hak-Kim ;

Fletcher, David F. ;

Chiou, Herbert .

PHARMACEUTICAL RESEARCH, 2007, 24 (08) :1450-1456

[8] The role of capsule on the performance of a dry powder inhaler using computational and experimental analyses [J].

Coates, MS ;

Fletcher, DF ;

Chan, HK ;

Raper, JA .

PHARMACEUTICAL RESEARCH, 2005, 22 (06) :923-932

[9] Effect of design on the performance of a dry powder inhaler using computational fluid dynamics. Part 1: Grid structure and mouthpiece length [J].

Coates, MS ;

Fletcher, DF ;

Chan, HK ;

Raper, JA .

JOURNAL OF PHARMACEUTICAL SCIENCES, 2004, 93 (11) :2863-2876

[10] Inhalation characteristics and their effects on in vitro drug delivery from dry powder inhalers .1. Inhalation characteristics, work of breathing and volunteers' preference in dependence of the inhaler resistance [J].

deBoer, AH ;

Winter, HMI ;

Lerk, CF .

INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1996, 130 (02) :231-244

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