Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes

被引：59

作者：

Duan, Faping ^{[1
]}

Curtis, Katherine L. ^{[1
]}

March, John C. ^{[1
]}

机构：

[1] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2008年 / 74卷 / 23期

关键词：

D O I：

10.1128/AEM.01019-08

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(-1) of insulin with no significant background secretion.

引用

页码：7437 / 7438

页数：2

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