Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes

被引：59

作者：

Duan, Faping ^{[1
]}

Curtis, Katherine L. ^{[1
]}

March, John C. ^{[1
]}

机构：

[1] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2008年 / 74卷 / 23期

关键词：

D O I：

10.1128/AEM.01019-08

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(-1) of insulin with no significant background secretion.

引用

页码：7437 / 7438

页数：2

共 50 条

[21] Gut commensal bacteria enhance pathogenesis of a tumorigenic murine retrovirus
Spring, Jessica
Khan, Aly A.
Lara, Sophie
O'Grady, Kelly
Wilks, Jessica
Gurbuxani, Sandeep
Erickson, Steven
Fischbach, Michael
Jacobson, Amy
Chervonsky, Alexander
Golovkina, Tatyana
CELL REPORTS, 2022, 40 (11):
[22] Nitrate reduction by commensal gut bacteria under physiological conditions
Tiso, Mauro
Schechter, Alan
NITRIC OXIDE-BIOLOGY AND CHEMISTRY, 2014, 42 : 145 - 146
[23] Functions of innate immune cells and commensal bacteria in gut homeostasis
Kayama, Hisako
Takeda, Kiyoshi
JOURNAL OF BIOCHEMISTRY, 2016, 159 (02): : 141 - 149
[24] Gut commensal bacteria, Paneth cells and their relations to radiation enteropathy
Gao, Yan-Li
Shao, Li-Hong
Dong, Li-Hua
Chang, Peng-Yu
WORLD JOURNAL OF STEM CELLS, 2020, 12 (03): : 188 - 202
[25] The Landscape of Adaptive Evolution of a Gut Commensal Bacteria in Aging Mice
Barreto, Hugo C.
Sousa, Ana
Gordo, Isabel
CURRENT BIOLOGY, 2020, 30 (06) : 1102 - +
[26] Serum antibodies to commensal oral and gut bacteria vary with age
Percival, RS
Marsh, PD
Challacombe, SJ
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY, 1996, 15 (01): : 35 - 42
[27] Roles of commensal gut bacteria and innate immunity in gastrointestinal inflammation
Heimesaat, M. M.
Fischer, A.
Blaut, M.
Liesenfeld, O.
Schumann, R. R.
Goebel, U. B.
Bereswill, S.
ZOONOSES AND PUBLIC HEALTH, 2007, 54 : 88 - 89
[28] Gut commensal bacteria show beneficial properties as wildlife probiotics
Stedman, Anna
van Vliet, Arnoud H. M.
Chambers, Mark A.
Gutierrez-Merino, Jorge
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 2020, 1467 (01) : 112 - 132
[29] Interleukin-1β secretion induced by mucosal-associated gut commensal bacteria promotes intestinal barrier repair
Wu, Wan-Jung
Kim, Myunghoo
Morales, Fatima Beatriz Saldana
Ruiz, Daniel Fernando Zegarra
Hill, Andrea
Song, Hyo Won
Norwood, Kendra
Diehl, Gretchen
JOURNAL OF IMMUNOLOGY, 2021, 206
[30] Interleukin-1β secretion induced by mucosa-associated gut commensal bacteria promotes intestinal barrier repair
Wu, Wan-Jung H.
Kim, Myunghoo
Chang, Lin-Chun
Assie, Adrien
Saldana-Morales, Fatima B.
Zegarra-Ruiz, Daniel F.
Norwood, Kendra
Samuel, Buck S.
Diehl, Gretchen E.
GUT MICROBES, 2022, 14 (01)

← 1 2 3 4 5 →