Secretion of Insulinotropic Proteins by Commensal Bacteria: Rewiring the Gut To Treat Diabetes

被引：59
|
作者：
Duan, Faping [1 ]
Curtis, Katherine L. [1 ]
March, John C. [1 ]
机构：
[1] Cornell Univ, Dept Biol & Environm Engn, Ithaca, NY 14853 USA
来源：
APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2008年 / 74卷 / 23期
关键词：
D O I：
10.1128/AEM.01019-08
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(-1) of insulin with no significant background secretion.
引用
收藏
页码：7437 / 7438
页数：2
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