Here, we show that commensal bacteria can stimulate intestinal epithelial cells to secrete insulin in response to glucose. Commensal strains were engineered to secrete the insulinotropic proteins GLP-1 and PDX-1. Epithelia stimulated by engineered strains and glucose secreted up to 1 ng ml(-1) of insulin with no significant background secretion.
机构:
Univ Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, CanadaUniv Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, Canada
Baggio, Laurie L.
Drucker, Daniel J.
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Univ Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, CanadaUniv Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, Canada
机构:
CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, FranceCEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Hazebrouck, Stephane
Pothelune, Laetitia
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h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Pothelune, Laetitia
Azevedo, Vasco
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h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Azevedo, Vasco
Corthier, Gerard
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h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Corthier, Gerard
Wal, Jean-Michel
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h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Wal, Jean-Michel
Langella, Philippe
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h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
机构:
Univ Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, CanadaUniv Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, Canada
Baggio, Laurie L.
Drucker, Daniel J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, CanadaUniv Toronto, Hosp Sick Children, Samuel Lunenfeld Res Inst, Dept Med,Banting & Best Diabet Ctr, Toronto, ON M5G 1X8, Canada
机构:
CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, FranceCEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Hazebrouck, Stephane
Pothelune, Laetitia
论文数: 0引用数: 0
h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Pothelune, Laetitia
Azevedo, Vasco
论文数: 0引用数: 0
h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Azevedo, Vasco
Corthier, Gerard
论文数: 0引用数: 0
h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Corthier, Gerard
Wal, Jean-Michel
论文数: 0引用数: 0
h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France
Wal, Jean-Michel
Langella, Philippe
论文数: 0引用数: 0
h-index: 0
机构:CEA Saclay, INRA, Unite Immuno Allergie Alimentaire, F-91191 Gif Sur Yvette, France