FOXOs: signalling integrators for homeostasis maintenance

被引：830
作者：
Eijkelenboom, Astrid [1 ]
Burgering, Boudewijn M. T. [1 ]
机构：
[1] Univ Med Ctr Utrecht, Div Biomed Genet, Univ Weg 100, NL-3584 CG Utrecht, Netherlands
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2013年 / 14卷 / 02期
关键词：
REGULATES AKT UBIQUITINATION; TRANSCRIPTION FACTORS; BETA-CATENIN; E3; LIGASE; INSULIN-RECEPTOR; FUNCTIONAL INTERACTION; NUCLEAR TRANSLOCATION; DEPENDENT REGULATION; CELL-PROLIFERATION; ELEGANS LONGEVITY;
D O I：
10.1038/nrm3507
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Forkhead box O (FOXO) transcription factors are involved in the regulation of the cell cycle, apoptosis and metabolism. In model organisms, FOXO activity also affects stem cell maintenance and lifespan as well as age-related diseases, such as cancer and diabetes. Multiple upstream pathways regulate FOXO activity through post-translational modifications and nuclear-cytoplasmic shuttling of both FOXO and its regulators. The diversity of this upstream regulation and the downstream effects of FOXOs suggest that they function as homeostasis regulators to maintain tissue homeostasis over time and coordinate a response to environmental changes, including growth factor deprivation, metabolic stress (starvation) and oxidative stress.
引用
收藏
页码：83 / 97
页数：15
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