Synthesis, Structure and Their Biological Activities of 3-[(5-H/methyl-benzoimidazol-2-yl)methylthio]-5-substituted-1,2,4-triazol-4-amine Derivatives

Seventeen 3-[(5-H/methyl-benzoimidazol-2-yl)methylthio]-5-substituted-1,2,4-triazol-4-amine derivatives were synthesized by the reaction of 4-amino-5-substituted-1,2,4-triazole-3-thiol with 2-chloromethyl-5-substituted-benzoimidazole in sodium hydroxide solution. All the compounds were characterized by H-1 NMR and IR spectra, and elemental analysis. Moreover, one novel cobalt(II) compound was obtained with the target compound 3f by solution method, and its structure was characterized by X-ray single crystal diffraction analysis. Besides, the results of primary biological activity experiments on wheat gemma and germination process of mung bean showed that these synthesized compounds had good activity, and the compounds 3d and 3i even have inhibiting effect on Staphylococcus aureus.