Association between endometriosis and polymorphisms in insulin-like growth factor binding protein genes in Korean women

Objective: Genetic factors are known to be associated with the development and progression of endometriosis, but the genes related to endometriosis have not been defined. Insulin-like growth factor binding proteins (IGFBPs) are believed to be involved in the proliferation and apoptosis of cells that play an important role in the pathophysiologic mechanism of endometriosis. This study aimed to determine the association between endometriosis and polymorphisms of the IGFBP genes in Korean women. Study design: In a case-control study, the rs1995051, rs1065780 and c.759A > G single nucleotide polymorphisms (SNPs) in the IGFBP1 gene and the -672A > G, -202A > C and c.95C > G SNPs in the IGFBP3 gene were analyzed in 128 women with endometriosis and 108 normal control women. Results: The haplotype genotype composed of a combination of three IGFBP1 gene polymorphisms was not related to endometriosis, while the haplotype genotype of the IGFBP3 gene had a significant association with endometriosis. Women not carrying the MG (-672A/-202A/c.95G) haplotype allele of three IGFBP3 gene polymorphisms have a 3.19-times higher risk of endometriosis compared with women with MG homozygotes, and this trend was found in women with advanced endometriosis but not in women with early endometriosis. Conclusions: The MG haplotype allele of the -672A > G, -202A > C and c.95C > G polymorphisms in the IGFBP3 gene may be associated with advanced endometriosis in Korean women. (C) 2012 Elsevier Ireland Ltd. All rights reserved.