Tumor-specific MAGE proteins as regulators of p53 function

被引：42
作者：
Fatima Ladelfa, Maria [2 ]
Peche, Leticia Yamila [1 ]
Fernanda Toledo, Maria [2 ]
Eva Laiseca, Julieta [2 ]
Schneider, Claudio [1 ,3 ]
Monte, Martin [2 ]
机构：
[1] Lab Nazl Consorzio Interuniv Biotecnol, I-34149 Trieste, Italy
[2] Univ Buenos Aires, FCEN, Dept Quim Biol, RA-1428 Buenos Aires, DF, Argentina
[3] Univ Udine, Dipartimento Sci & Tecnol Biomed, I-33100 Udine, Italy
来源：
CANCER LETTERS | 2012年 / 325卷 / 01期
关键词：
MAGE; p53; Transcriptional inhibition; Anticancer therapies; MELANOMA-ASSOCIATED ANTIGEN; NUCLEAR COREPRESSOR KAP1; ANDROGEN RECEPTOR; NEUROTROPHIN RECEPTOR; CELL-PROLIFERATION; GROWTH SUPPRESSOR; CANCER; APOPTOSIS; GENE; EXPRESSION;
D O I：
10.1016/j.canlet.2012.05.031
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Since its discovery in 1991, the knowledge about the tumor specific melanoma antigen gene (MAGE-I) family has been continuously increasing. Initially. MAGE-I proteins were considered as selective targets for immunotherapy. More recently, emerging data obtained from different cellular mechanisms controlled by MACE-I proteins suggest a key role in the regulation of important pathways linked to cell proliferation. This is in part due to the ability of some MAGE-I proteins to control the p53 tumor suppressor. In this review, we focus on the mechanisms proposed to explain how MAGE-I proteins affect p53 functions. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：11 / 17
页数：7
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