Remarkable DNA binding affinity and potential anticancer activity of pyrrolo[2,1-c][1,4]benzodiazepine-naphthalimide conjugates linked through piperazine side-armed alkane spacers

被引：49

作者：

Kamal, Ahmed ^{[1
]}

Ramu, R. ^{[1
]}

Tekumalla, Venkatesh ^{[1
]}

Khanna, G. B. Ramesh ^{[1
]}

Barkume, Madan S. ^{[2
]}

Juvekar, Aarti S. ^{[2
]}

Zingde, Surekha M. ^{[2
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500607, Andhra Pradesh, India

[2] Tata Mem Ctr Khargar, Adv Ctr Treatment Res & Educ Canc, Navi Mumbai 410210, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2008年 / 16卷 / 15期

关键词：

pyrrolobenzodiazepines; naphthalimides; piperazine ring; DNA binding affinity; anticancer activity;

D O I：

10.1016/j.bmc.2008.06.034

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A series of pyrrolobenzodiazepine-naphthalimide conjugates tethered through a piperazine ring system have been designed, synthesized, and evaluated for their anticancer activity. These new conjugates exhibit very high DNA binding affinity and cytotoxic activity against a number of cell lines. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：7218 / 7224

页数：7

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