Natural Killer Cells to the Attack: Combination Therapy against Neuroblastoma

被引：11
作者：
Zenarruzabeitia, Olatz [1 ]
Vitalle, Joana [1 ]
Astigarraga, Itziar [2 ,3 ,4 ]
Borrego, Francisco [1 ,5 ,6 ]
机构：
[1] BioCruces Hlth Res Inst, Immunopathol Grp, Baracaldo, Spain
[2] BioCruces Hlth Res Inst, Pediat Oncol Grp, Baracaldo, Spain
[3] Cruces Univ Hosp, Serv Pediat, Baracaldo, Spain
[4] Univ Basque Country, Fac Med & Dent, Dept Pediat, Leioa, Spain
[5] Ctr Transfus & Human Tissues, Immunotherapy Grp, Galdakao, Spain
[6] Basque Fdn Sci, Ikerbasque, Bilbao, Spain
来源：
CLINICAL CANCER RESEARCH | 2017年 / 23卷 / 03期
关键词：
ANTI-GD2; ANTIBODY; CANCER; DINUTUXIMAB;
D O I：
10.1158/1078-0432.CCR-16-2478
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
TGF beta in the tumor microenvironment diminishes natural killer (NK) cell-mediated anti-disialoganglioside (anti-GD2) mAb elimination of neuroblastoma cells. Consequently, blockade of TGFb signaling with galunisertib in combination with the anti-GD2 mAb dinutuximab plus adoptively transferred NK cells is a promising tool for the treatment of neuroblastoma. (C) 2016 AACR.
引用
收藏
页码：615 / 617
页数：3
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