Surgical Management of Neurofibromatosis

被引：10
作者：
Parsons, Colin M. [1 ]
Canter, Robert J. [1 ]
Khatri, Vijay P. [1 ]
机构：
[1] Univ Calif Davis, Div Surg Oncol, Med Ctr, Dept Surg, Sacramento, CA 95817 USA
来源：
SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 18卷 / 01期
关键词：
Neurofibromatosis; Malignant peripheral nerve sheath tumor; Genetics; Schwannoma; NERVE SHEATH TUMORS; POSITRON-EMISSION-TOMOGRAPHY; SOFT-TISSUE SARCOMAS; TYPE-1; NEUROFIBROMATOSIS; PLEXIFORM NEUROFIBROMAS; VESTIBULAR SCHWANNOMAS; HEARING PRESERVATION; FDG-PET; VONRECKLINGHAUSEN NEUROFIBROMATOSIS; MALIGNANT-TRANSFORMATION;
D O I：
10.1016/j.soc.2008.08.009
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Neurofibromatoses are a complex set of genetic diseases with a wide spectrum of clinical manifestations. Life-threatening complications may develop as the result of tumor progression. Surgical intervention is the only effective means of treatment for progressive pain, disfigurement, functional compromise, and malignancy. In the future, molecular advances should allow for the development of targeted therapies to treat patients who have neurofibromatosis in addition to those who have sporadic tumors. Tumor profiling should allow us to guide therapies and predict responses.
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页码：175 / +
页数：23
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