The Steroid Spectrum During and After Quitting Smoking

被引:9
作者
Jandikova, H. [1 ]
Duskova, M. [1 ]
Simunkova, K. [1 ,2 ,3 ]
Racz, B. [1 ]
Hill, M. [1 ]
Kralikova, E. [3 ,4 ,5 ]
Vondra, K. [1 ]
Starka, L. [1 ]
机构
[1] Inst Endocrinol, Narodni 8, Prague 11694 1, Czech Republic
[2] Charles Univ Prague, Fac Med 1, Dept Internal Med 3, Prague, Czech Republic
[3] Gen Univ Hosp, Prague, Czech Republic
[4] Charles Univ Prague, Ctr Tobacco Dependence, Dept Med 3, Dept Endocrinol & Metab,Fac Med 1, Prague, Czech Republic
[5] Charles Univ Prague, Inst Hyg & Epidemiol, Fac Med 1, Prague, Czech Republic
关键词
Men; Smoking cessation; Prediction; SHBG; Testosterone; CIGARETTE-SMOKING; SEX-HORMONES; TESTOSTERONE; CESSATION; WEIGHT; MEN; PROLACTIN; NICOTINE; IMPACT;
D O I
10.33549/physiolres.933068
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Addiction to tobacco results in an imbalance of endocrine homeostasis in both sexes. This can also have impacts on fertility problems. The male reproductive system is less susceptible than that of females, with a worsening spermiogram in smokers, the most cited effect in the literature. However, the literature is inconsistent as to the effects of smoking on steroid hormone levels in men, and there is very little data on the effects of quitting smoking in men. In this study we followed 76 men before quitting smoking, and then after 6, 12, and 24 weeks and 1 year of abstinence. We measured basic anthropomorphic data and steroid hormone levels along with steroid neuroactive metabolites using GC-MS. We demonstrate lower androgen levels in men who smoke, and these changes worsened after quitting smoking. There was a drop in SHBG already in the first week of non-smoking, and levels continued to remain low. Male smokers have lower androgen levels compared to non-smokers. The lower the initial level of androgen, the lower the likelihood of success in quitting smoking. Changes in steroid hormones proved to be a promising marker for the prediction of success in quitting smoking.
引用
收藏
页码:S211 / S218
页数:8
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