Duodenal intraepithelial lymphocytosis in Helicobacter pylori gastritis: comparison before and after treatment

被引：4

作者：

Bosch, Dustin E. ^{[1
]}

Liu, Yong-Jun ^{[1
,2
]}

Truong, Camtu D. ^{[1
,3
]}

Lloyd, Kelly A. ^{[1
,4
]}

Swanson, Paul E. ^{[1
]}

Upton, Melissa P. ^{[1
]}

Yeh, Matthew M. ^{[1
,5
]}

机构：

[1] Univ Washington, Dept Lab Med & Pathol, Sch Med, 1959 NE Pacific St,NE140D,Box 356100, Seattle, WA 98195 USA

[2] Univ Wisconsin, Dept Pathol & Lab Med, Sch Med & Publ Hlth, Madison, WI USA

[3] Vet Affairs Puget Sound Hlth Care Syst, Dept Pathol, Seattle, WA USA

[4] Northwest Pathol, Bellingham, WA USA

[5] Univ Washington, Sch Med, Dept Med, Seattle, WA 98195 USA

来源：

VIRCHOWS ARCHIV | 2021年 / 478卷 / 04期

关键词：

H; pylori; Gastritis; Duodenal lymphocytosis; Gastrointestinal; VILLOUS ARCHITECTURE; CELIAC-DISEASE; COMMON;

D O I：

10.1007/s00428-020-02941-2

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Our aims were to assess performance of duodenal intraepithelial lymphocyte counting for diagnosis ofHelicobacter pylori(H.pylori) gastritis, and effects of eradication therapy on intraepithelial lymphocytosis. Paired duodenal and gastric biopsies from subjects with a pathologic diagnosis ofH.pylorigastritis were reviewed. Higher duodenal intraepithelial lymphocyte counts were observed in 40 subjects withH.pylorigastritis (26 +/- 5 per villus) than 52 subjects negative forH.pylori(12 +/- 2 per villus). After successful eradication therapy, duodenal lymphocytes were indistinguishable fromH.pylori-negative subjects, whereas they remained elevated after failed eradication therapy. This study confirms previous reports of increased duodenal intraepithelial lymphocytes in patients with concurrentHelicobacter pylorigastritis. Intraepithelial lymphocyte counts of > 15 per villus or > 10 per 100 enterocytes were predictive of infection. Duodenal lymphocytosis decreases significantly after successful eradication therapy but remains elevated when treatment fails.

引用

页码：805 / 809

页数：5

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