Ultrasound aided solvent-free synergy: an improved synthetic approach to access 3,4-dihydropyrimidin-2(1H)-ones

被引：5

作者：

Ramesh, Rathinam ^{[1
]}

Ramesh, Samikannu ^{[1
]}

Malecki, Jan Grzegorz ^{[2
]}

Lalitha, Appaswami ^{[1
]}

机构：

[1] Periyar Univ, Dept Chem, Salem 636011, Tamil Nadu, India

[2] Univ Silesia, Dept Crystallog, Szkolna 9, PL-40007 Katowice, Poland

来源：

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY | 2019年 / 16卷 / 06期

关键词：

3,4-Dihydropyrimidin-2(1H)-ones; Solvent-free synthesis; Trichlorotriazine; X-ray analysis; Ultrasound; ONE-POT SYNTHESIS; HETEROGENEOUS CATALYST; EFFICIENT CATALYSTS; BIGINELLI REACTION; SOLID ACID; NANOPARTICLES; DERIVATIVES;

D O I：

10.1007/s13738-019-01597-3

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A remarkably simple synthetic method has been described for the access of structurally diverse 3,4-dihydropyrimidin-2(1H)-ones in excellent yields in the presence of 2,4,6-trichloro-1,3,5-triazine (TCT) as an efficient source of hydrochloric acid under ultrasound radiation. In this tandem reaction, a range of aldehydes, -diketo esters and urea were made to condense together via one-pot, solvent-free synthetic strategy. Use of metal-free catalyst, readily accessible substrates, high production rate and ease of work-up are the imperative features of this protocol. [GRAPHICS] .

引用

页码：1197 / 1205

页数：9

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