One-pot tandem cyclisation to pyrrolo[1,2-a][1,4]benzodiazepines: a modified approach to the Pictet-Spengler reaction

被引：16

作者：

Ali, Sk Asraf ^{[1
,4
]}

Mondal, Suresh Kumar ^{[1
]}

Das, Tapas ^{[2
]}

Manna, Susanta Kumar ^{[1
]}

Bera, Anirban ^{[1
]}

Dafadar, Debabrata ^{[1
]}

Naskar, Sourenjit ^{[3
]}

Molla, Mijanur Rahaman ^{[4
]}

Samanta, Shubhankar ^{[1
]}

机构：

[1] Bidhannagar Coll, Dept Chem, Kolkata 700064, India

[2] Natl Inst Technol, Jamshedpur 831014, Jharkhand, India

[3] Indian Assoc Cultivat Sci, Kolkata 700032, India

[4] Univ Calcutta, Dept Chem, Acharya Prafulla Chandra Rd, Kolkata 700009, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 18期

关键词：

EFFICIENT SYNTHESIS; ATOM ECONOMY; HETEROCYCLES; DERIVATIVES; PYRROLE; CATALYST; FACILE;

D O I：

10.1039/c9ob00448c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

We have reported a one-pot two-step methodology for the synthesis of highly condensed heterocycles, pyrrolo[1,2-a][1,4] benzodiazepines, by a modified Pictet-Spengler reaction under mild conditions in a short time. Our approach has a few advantages over the conventional two components synthesis as it is step and atom economic, environmentally benign and a convergent synthetic method. We have discussed here the broad substrate scope of this novel methodology.

引用

页码：4652 / 4662

页数：11

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