Direct C-2 Alkylation of Quinoline N-Oxides with Ethers via Palladium-Catalyzed Dehydrogenative Cross-Coupling Reaction

被引：134

作者：

Wu, Zhiyong ^{[1
]}

Pi, Chao ^{[1
]}

Cui, Xiuling ^{[1
,2
]}

Bai, Jie ^{[1
]}

Wu, Yangjie ^{[1
]}

机构：

[1] Zhengzhou Univ, Dept Chem, Henan Key Lab Chem Biol & Organ Chem, Key Lab Appl Chem Henan Univ, Zhengzhou 450052, Peoples R China

[2] Huaqiao Univ, Sch Biomed Sci, Res Ctr Mol Med,Inst Mol Med, Chinese Educ Minist,Xiamen Key Lab Ocean & Gene D, Xiamen 361021, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 10期

关键词：

alkylation; CH bond activation; palladium-catalyzed reaction; quinoline N-oxides; FREE-RADICAL REACTIONS; C-H BOND; HETEROAROMATIC BASES; FUNCTIONALIZATION; ACTIVATION; ADJACENT;

D O I：

10.1002/adsc.201300111

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient and concise one-pot strategy for the direct alkylation of quinoline N-oxides via palladium-catalyzed dual C-H bonds activation has been developed. This methodology provides quinoline-containing heterocyclic molecules in moderate to excellent yields.

引用

页码：1971 / 1976

页数：6

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