Hereditary Gingival Fibromatosis: Report of Family Pedigree of three Generations

Gingival enlargement or gingival overgrowth can be defined as increase in the size of gingiva, caused due to a variety of etiological factors. One of the causes of gingival enlargement is hereditary gingival fibromatosis, which is a genetic disorder characterised by progressive enlargement of the free and attached gingiva. It may have a nodular enlargement, having stippled surfaces with no inflammation or may show inflamed surface. Clinically, gingiva may present dense or firm surface on palpation. It is commonly associated with mutation of Son of Sevenless-1 (SOS-1) gene, which is responsible for this disease. This case report focuses on a family, diagnosed with hereditary gingival fibromatosis in three consecutive generations. This report also discusses the diagnosis, treatment, histopathological features and the pattern of inheritance associated, which is emphasised through pedigree analysis.