Ascorbic acid: much more than just an antioxidant

被引：795
作者：
Arrigoni, O [1 ]
De Tullio, MC [1 ]
机构：
[1] Univ Bari, Dipartimento BIol & Patol Vegetale, I-70125 Bari, Italy
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS | 2002年 / 1569卷 / 1-3期
关键词：
ascorbic acid; dehydroascorbic acid; oxoglutarate-dependent dioxygenase;
D O I：
10.1016/S0304-4165(01)00235-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vitamin C (ascorbic acid (AA)) is very popular for its antioxidant properties. Consequently, many other important aspects of this multifaceted molecule are often underestimated or even ignored. In the present paper, we have tried to bring to the foreground some of these aspects, including the peculiarities of the AA biosynthetic pathway in different organisms, the remarkable function of AA as a co-substrate of many important dioxygenases, the role of AA-regenerating enzymes and the known pathways of AA catabolism, as well as the intriguing function of AA in gene expression. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：1 / 9
页数：9
相关论文
共 121 条
[1]  
ALCAIN FJ, 1990, CANCER RES, V50, P5887
[2]   OXIDANTS, ANTIOXIDANTS, AND THE DEGENERATIVE DISEASES OF AGING [J].
AMES, BN ;
SHIGENAGA, MK ;
HAGEN, TM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (17) :7915-7922
[3]   ASCORBATE SYSTEM IN PLANT DEVELOPMENT [J].
ARRIGONI, O .
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 1994, 26 (04) :407-419
[4]   CHANGES IN THE ASCORBATE SYSTEM DURING SEED DEVELOPMENT OF VICIA-FABA L [J].
ARRIGONI, O ;
DEGARA, L ;
TOMMASI, F ;
LISO, R .
PLANT PHYSIOLOGY, 1992, 99 (01) :235-238
[5]   The role of ascorbic acid in cell metabolism: between gene-directed functions and unpredictable chemical reactions [J].
Arrigoni, O ;
De Tullio, MC .
JOURNAL OF PLANT PHYSIOLOGY, 2000, 157 (05) :481-488
[6]  
ARRIGONI O, 1957, REND ACC NAZ LINCEI, V23, P287
[7]   Ascorbate metabolism and its regulation in animals [J].
Banhegyi, G ;
Braun, L ;
Csala, M ;
Puskas, F ;
Mandl, J .
FREE RADICAL BIOLOGY AND MEDICINE, 1997, 23 (05) :793-803
[8]   Ascorbate biosynthesis in mitochondria is linked to the electron transport chain between complexes III and IV [J].
Bartoli, CG ;
Pastori, GM ;
Foyer, CH .
PLANT PHYSIOLOGY, 2000, 123 (01) :335-343
[9]  
Baum Jean, 1999, Current Opinion in Structural Biology, V9, P122, DOI 10.1016/S0959-440X(99)80016-5
[10]   THE OXIDATION OF REDUCED DIPHOSPHOPYRIDINE NUCLEOTIDE BY AN ASCORBATE SYSTEM FROM CUCUMBER [J].
BEEVERS, H .
PLANT PHYSIOLOGY, 1954, 29 (03) :265-269
12345678910