Shedding light on gene therapy: Carbon dots for the minimally invasive image-guided delivery of plasmids and noncoding RNAs - A review

被引：102

作者：

Mohammadinejad, Reza ^{[1
]}

Dadashzadeh, Arezoo ^{[2
]}

Moghassemi, Saeid ^{[2
]}

Ashrafizadeh, Milad ^{[3
]}

Dehshahri, Ali ^{[4
]}

Pardakhty, Abbas ^{[1
]}

Sassan, Hosseinali ^{[5
]}

Sohrevardi, Seyed-Mojtaba ^{[6
]}

Mandegary, Ali ^{[7
,8
]}

机构：

[1] Kerman Univ Med Sci, Pharmaceut Res Ctr, Inst Neuropharmacol, Kerman, Iran

[2] Amirkabir Univ Technol, Dept Biomed Engn, Tehran, Iran

[3] Univ Tabriz, Fac Vet Med, Dept Basic Sci, Tabriz, Iran

[4] Shiraz Univ Med Sci, Sch Pharm, Dept Pharmaceut Biotechnol, POB 71345-1583, Shiraz, Iran

[5] Shahid Bahonar Univ, Fac Sci, Dept Biol, Kerman, Iran

[6] Shahid Sadoughi Univ Med Silences, Fac Pharm, Pharmaceut Sci Res Ctr, Yazd, Iran

[7] Kerman Univ Med Sci, Neurosci Res Ctr, Inst Neuropharmacol, Sch Pharm, Kerman, Iran

[8] Kerman Univ Med Sci, Sch Pharm, Dept Toxicol & Pharmacol, Kerman, Iran

来源：

JOURNAL OF ADVANCED RESEARCH | 2019年 / 18卷

关键词：

Cationic carbon dots; Fluorescent; Surface passivation; Bioimaging; Gene delivery; Theranostics; GRAPHENE QUANTUM DOTS; ONE-STEP SYNTHESIS; LARGE-SCALE SYNTHESIS; NUCLEIC-ACID; IN-VITRO; PHOTOLUMINESCENCE MECHANISM; HYDROTHERMAL SYNTHESIS; POLYETHYLENE-GLYCOL; FLUORESCENT-PROBES; FOLATE RECEPTOR;

D O I：

10.1016/j.jare.2019.01.004

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Recently, carbon dots (CDs) have attracted great attention due to their superior properties, such as biocompatibility, fluorescence, high quantum yield, and uniform distribution. These characteristics make CDs interesting for bioimaging, therapeutic delivery, optogenetics, and theranostics. Photoluminescence (PL) properties enable CDs to act as imaging-trackable gene nanocarriers, while cationic CDs with high transfection efficiency have been applied for plasmid DNA and siRNA delivery. In this review, we have highlighted the precursors, structure and properties of positively charged CDs to demonstrate the various applications of these materials for nucleic acid delivery. Additionally, the potential of CDs as trackable gene delivery systems has been discussed. Although there are several reports on cellular and animal approaches to investigating the potential clinical applications of these nanomaterials, further systematic multidisciplinary approaches are required to examine the pharmacokinetic and biodistribution patterns of CDs for potential clinical applications. (C) 2019 The Authors. Published by Elsevier B.V. on behalf of Cairo University.

引用

页码：81 / 93

页数：13

共 133 条

[1] Target Delivery and Cell Imaging Using Hyaluronic Acid-Functionalized Graphene Quantum Dots [J].