Plasma adipokines and endometriosis risk: a prospective nested casecontrol investigation from the Nurses Health Study II

被引:13
作者
Shah, Divya K. [1 ]
Correia, Katharine F. [2 ,3 ]
Harris, Holly R. [5 ]
Missmer, Stacey A. [2 ,3 ,4 ,5 ]
机构
[1] Univ Iowa Hosp & Clin, Dept Obstet & Gynecol, Div Reprod Endocrinol & Infertil, Iowa City, IA 52242 USA
[2] Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA
[3] Harvard Univ, Sch Med, Boston, MA 02115 USA
[4] Brigham & Womens Hosp, Dept Med, Channing Lab, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
关键词
leptin; adiponectin; adipokines; endometriosis; PERITONEAL-FLUID; LEPTIN CONCENTRATIONS; ADIPONECTIN; WEIGHT; WOMEN; SERUM; ASSOCIATION; PROTEIN;
D O I
10.1093/humrep/des411
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Do higher leptin levels and lower adiponectin levels predict subsequent development of endometriosis? Plasma leptin and adiponectin levels were not associated with laparoscopically confirmed endometriosis when collected prior to disease diagnosis. Casecontrol studies have identified altered levels of the inflammatory adipokines leptin and adiponectin in women with endometriosis, but it remains unclear whether inflammation results in endometriosis or whether the presence of endometriosis creates an inflammatory state. Nested, matched, casecontrol study within the prospective Nurses Health Study II (NHS II) cohort. Blood samples were collected between 1996 and 1999 from 29 611 female nurses within the cohort. Women who reported endometriosis before blood collection were excluded. Plasma leptin and adiponectin levels were assayed by ELISA. Three hundred and fifty cases of laparoscopically confirmed endometriosis were matched 1:2 with 694 controls of comparable race, age, infertility history, menopausal status and time of blood draw. Relative risks (RRs) and 95 confidence intervals (CIs) were calculated using unconditional logistic regression models adjusting for matching factors and BMI. After adjusting for BMI, there were no statistically significant associations between endometriosis and leptin [RR 1.2; 95 CI 0.72.0; P-value, test for linear trend (P-trend) 0.72], adiponectin (RR 0.8; 95 CI 0.51.2; P-trend 0.48) or the leptin to adiponectin ratio (RR 0.8; 95 CI 0.41.4; P-trend 0.14) when comparing the upper with the lower quartile. Results were unaltered when analyses were stratified by BMI or restricted to cases diagnosed epsilon 4 years after blood draw. To evaluate statistical significance and limit the role of chance to the gold standard of 5, we present 95 CIs about the RRs, and for P-values calculated for linear tests of trend and tests of heterogeneity, we have set the -level to be 0.05 (i.e. 0.05 is considered to be statistically significant). A limitation of this study is the inability to differentiate the time of endometriosis odiagnosis' from the time of disease oonset' due to the impossibility in identifying a precise time point at which the disease process was first initiated at a molecular or cellular level. Additional limitations include lack of information regarding stage of endometriosis and the possibility of asymptomatic disease in the control population. The mean age at diagnosis of endometriosis in the study population is 41.7, approximate to 10 years older than the mean age of diagnosis in the general population. While this may limit the generalizability of the results, there is no reason to suspect that the association between adipokines and endometriosis risk should differ at a younger age of diagnosis in an adult population. This study was supported by research grants HD48544, HD52473 and HD57210 from the Eunice Kennedy Shriver National Institute of Child Health and Human Development. The NHS II is supported by the Public Health Service grant CA50385 from the National Cancer Institute, NIH, U.S. Department of Health and Human Services. H.R.H. is supported by NIH training grant T32 ES007069 and MCHB grant number 5T76MC00001 (formerly MCJ201).
引用
收藏
页码:315 / 321
页数:7
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